Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1/miR-134 signalling pathway regulates CREB/BDNF expression in hippocampus in vivo and in vitro

•Resveratrol prevents cognitive impairment induced by chronic unpredictable mild stress.•Resveratrol treatment increases Sirt1, p-CREB, CREB, BDNF expression and decreases miR134 levels in hippocampus.•The effects of resveratrol are mediated by activating Sirt1/miR134 pathway. Chronic unpredictable...

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Veröffentlicht in:	Behavioural brain research 2018-09, Vol.349, p.1-7
Hauptverfasser:	Shen, Jun, Xu, Linling, Qu, Chujie, Sun, Huimin, Zhang, Junjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronic unpredictable mild stress Cognitive impairment miR-134 Resveratrol Sirt1
Online-Zugang:	Volltext
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