Quinone-Induced Enhancement of DNA Cleavage by Human Topoisomerase II sub( alpha ): Adduction of Cysteine Residues 392 and 405

Several quinone-based metabolites of drugs and environmental toxins are potent topoisomerase II poisons. These compounds act by adducting the protein and appear to increase levels of enzyme-DNA cleavage complexes by at least two potentially independent mechanisms. Treatment of topoisomerase II a wit...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2007-03, Vol.46 (10), p.2856-2864
Hauptverfasser:	Bender, R P, Ham, A-JL, Osheroff, N
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!