MAPK/ERK signal pathway alterations in patients with Langerhans Cell Histiocytosis

Clinical outcomes of Langerhans cell histiocytosis (LCH) are highly variable. It has been suggested that mitogen-activated protein kinase (MAPK) /extracellular signal-regulated kinases (ERK) signaling pathway might be activated in LCH patients. We investigated KRAS, BRAF and NRAS mutations in patien...

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Veröffentlicht in:	Klinická onkologie 2018, Vol.31 (2), p.130-136
Hauptverfasser:	Novosad, Olga, Skrypets, Tanya, Pastushenko, Yan, Titorenko, Iryna, Martynchyk, Arina, Skachkova, Oksana, Inomistova, Mariia, Gorbach, Alex, Khranovska, Nataliia, Kryachok, Irina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Female GTP Phosphohydrolases - genetics Histiocytosis, Langerhans-Cell - genetics Humans Male MAP Kinase Signaling System Membrane Proteins - genetics Middle Aged Mutation Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Young Adult
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