Patterns of Progressive Ganglion Cell–Inner Plexiform Layer Thinning in Glaucoma Detected by OCT
To investigate the spatial characteristics and patterns of progressive macular ganglion cell–inner plexiform layer (GCIPL) thinning in glaucomatous eyes assessed by OCT Guided Progression Analysis (GPA). Longitudinal, retrospective, observational study. Two hundred ninety-two eyes of 192 patients wi...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 2018-10, Vol.125 (10), p.1515-1525 |
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| description | To investigate the spatial characteristics and patterns of progressive macular ganglion cell–inner plexiform layer (GCIPL) thinning in glaucomatous eyes assessed by OCT Guided Progression Analysis (GPA).
Longitudinal, retrospective, observational study.
Two hundred ninety-two eyes of 192 patients with primary open-angle glaucoma with a mean follow-up of 6.0 years (range, 3.2–8.1 years) were included.
Macular GCIPL imaging and visual field (VF) examination were performed at 6-month intervals for 3 years or more. Progressive GCIPL thinning was evaluated by a Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) GPA device. Spatial characteristics of progressive GCIPL thinning were assessed by the GCIPL thickness change map. The pattern of progressive GCIPL thinning was evaluated by comparing the baseline GCIPL thickness deviation map and the final GCIPL thickness change map. Visual field progression was determined by Early Manifest Glaucoma Trial criteria and linear regression of the VF index.
Spatial characteristics and patterns of progressive GCIPL thinning.
Seventy-two eyes of 62 participants (24.7% [72/292]) showed progressive GCIPL thinning in the GCIPL thickness change map. Progressive GCIPL thinning was detected most frequently (25.0%) at 2.08 mm from the fovea, and it extended in an arcuate shape in the inferotemporal region (250°–339°). Compared with the baseline GCIPL defects, the progressive GCIPL thinning extended toward the fovea and optic disc. The most common pattern of progressive GCIPL thinning was widening of GCIPL defects (42 eyes [58.3%]), followed by deepening of GCIPL defects (19 eyes [26.4%]) and newly developed GCIPL defects (15 eyes [20.8%]). Visual field progression was accompanied by progressive GCIPL thinning in 41 of 72 eyes (56.9%). Progressive GCIPL thinning preceded (61.0% [25/41]) or occurred concomitantly with (21.9% [9/41]) VF progression.
The use of OCT GPA maps offers an effective approach to evaluate the topographic patterns of progressive GCIPL thinning in glaucomatous eyes. Progression of GCIPL thinning occurred before apparent progression on standard automated perimetry in most glaucomatous eyes. Understanding specific patterns and sequences of macular damage may provide important insights in the monitoring of glaucomatous progression. |
| doi_str_mv | 10.1016/j.ophtha.2018.03.052 |
| format | Article |
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Longitudinal, retrospective, observational study.
Two hundred ninety-two eyes of 192 patients with primary open-angle glaucoma with a mean follow-up of 6.0 years (range, 3.2–8.1 years) were included.
Macular GCIPL imaging and visual field (VF) examination were performed at 6-month intervals for 3 years or more. Progressive GCIPL thinning was evaluated by a Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) GPA device. Spatial characteristics of progressive GCIPL thinning were assessed by the GCIPL thickness change map. The pattern of progressive GCIPL thinning was evaluated by comparing the baseline GCIPL thickness deviation map and the final GCIPL thickness change map. Visual field progression was determined by Early Manifest Glaucoma Trial criteria and linear regression of the VF index.
Spatial characteristics and patterns of progressive GCIPL thinning.
Seventy-two eyes of 62 participants (24.7% [72/292]) showed progressive GCIPL thinning in the GCIPL thickness change map. Progressive GCIPL thinning was detected most frequently (25.0%) at 2.08 mm from the fovea, and it extended in an arcuate shape in the inferotemporal region (250°–339°). Compared with the baseline GCIPL defects, the progressive GCIPL thinning extended toward the fovea and optic disc. The most common pattern of progressive GCIPL thinning was widening of GCIPL defects (42 eyes [58.3%]), followed by deepening of GCIPL defects (19 eyes [26.4%]) and newly developed GCIPL defects (15 eyes [20.8%]). Visual field progression was accompanied by progressive GCIPL thinning in 41 of 72 eyes (56.9%). Progressive GCIPL thinning preceded (61.0% [25/41]) or occurred concomitantly with (21.9% [9/41]) VF progression.
The use of OCT GPA maps offers an effective approach to evaluate the topographic patterns of progressive GCIPL thinning in glaucomatous eyes. Progression of GCIPL thinning occurred before apparent progression on standard automated perimetry in most glaucomatous eyes. Understanding specific patterns and sequences of macular damage may provide important insights in the monitoring of glaucomatous progression.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/j.ophtha.2018.03.052</identifier><identifier>PMID: 29705057</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Disease Progression ; Female ; Follow-Up Studies ; Glaucoma, Open-Angle - diagnosis ; Humans ; Intraocular Pressure - physiology ; Male ; Middle Aged ; Nerve Fibers - pathology ; Optic Disk - pathology ; Retinal Ganglion Cells - pathology ; Retrospective Studies ; Time Factors ; Tomography, Optical Coherence - methods ; Visual Acuity ; Visual Fields - physiology</subject><ispartof>Ophthalmology (Rochester, Minn.), 2018-10, Vol.125 (10), p.1515-1525</ispartof><rights>2018 American Academy of Ophthalmology</rights><rights>Copyright © 2018 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-a0eafc1107ba01fc8e359da216c6545e3f9c1bce68d9ff8d5d9058dca384f4a3</citedby><cites>FETCH-LOGICAL-c428t-a0eafc1107ba01fc8e359da216c6545e3f9c1bce68d9ff8d5d9058dca384f4a3</cites><orcidid>0000-0002-5063-2685</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161642018300447$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29705057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Joong Won</creatorcontrib><creatorcontrib>Sung, Kyung Rim</creatorcontrib><creatorcontrib>Park, Sun-Won</creatorcontrib><title>Patterns of Progressive Ganglion Cell–Inner Plexiform Layer Thinning in Glaucoma Detected by OCT</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>To investigate the spatial characteristics and patterns of progressive macular ganglion cell–inner plexiform layer (GCIPL) thinning in glaucomatous eyes assessed by OCT Guided Progression Analysis (GPA).
Longitudinal, retrospective, observational study.
Two hundred ninety-two eyes of 192 patients with primary open-angle glaucoma with a mean follow-up of 6.0 years (range, 3.2–8.1 years) were included.
Macular GCIPL imaging and visual field (VF) examination were performed at 6-month intervals for 3 years or more. Progressive GCIPL thinning was evaluated by a Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) GPA device. Spatial characteristics of progressive GCIPL thinning were assessed by the GCIPL thickness change map. The pattern of progressive GCIPL thinning was evaluated by comparing the baseline GCIPL thickness deviation map and the final GCIPL thickness change map. Visual field progression was determined by Early Manifest Glaucoma Trial criteria and linear regression of the VF index.
Spatial characteristics and patterns of progressive GCIPL thinning.
Seventy-two eyes of 62 participants (24.7% [72/292]) showed progressive GCIPL thinning in the GCIPL thickness change map. Progressive GCIPL thinning was detected most frequently (25.0%) at 2.08 mm from the fovea, and it extended in an arcuate shape in the inferotemporal region (250°–339°). Compared with the baseline GCIPL defects, the progressive GCIPL thinning extended toward the fovea and optic disc. The most common pattern of progressive GCIPL thinning was widening of GCIPL defects (42 eyes [58.3%]), followed by deepening of GCIPL defects (19 eyes [26.4%]) and newly developed GCIPL defects (15 eyes [20.8%]). Visual field progression was accompanied by progressive GCIPL thinning in 41 of 72 eyes (56.9%). Progressive GCIPL thinning preceded (61.0% [25/41]) or occurred concomitantly with (21.9% [9/41]) VF progression.
The use of OCT GPA maps offers an effective approach to evaluate the topographic patterns of progressive GCIPL thinning in glaucomatous eyes. Progression of GCIPL thinning occurred before apparent progression on standard automated perimetry in most glaucomatous eyes. Understanding specific patterns and sequences of macular damage may provide important insights in the monitoring of glaucomatous progression.</description><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Optic Disk - pathology</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Visual Acuity</subject><subject>Visual Fields - physiology</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM-O0zAQhy0EYsvCGyDkI5eEcWynyQUJFSgrVdoeercce9y6Suxipyt64x14Q54Er7pw5DQa6fvNn4-QtwxqBqz9cKzj6TAfdN0A62rgNcjmGVkwKfpKLBl_ThYFY1UrGrghr3I-AkDbcvGS3DT9EiTI5YIMWz3PmEKm0dFtivuEOfsHpGsd9qOPga5wHH___HUXAia6HfGHdzFNdKMvpd8dfAg-7KkPdD3qs4mTpp9xRjOjpcOF3q92r8kLp8eMb57qLdl9_bJbfas29-u71adNZUTTzZUG1M4wBstBA3OmQy57qxvWmlYKidz1hg0G2872znVW2h5kZ43mnXBC81vy_jr2lOL3M-ZZTT6bcrwOGM9ZNcCbDriQbUHFFTUp5pzQqVPyk04XxUA9ylVHdZWrHuUq4KrILbF3TxvOw4T2X-ivzQJ8vAJY3nzwmFQ2HoNB61Mxomz0_9_wBzq7jsA</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Shin, Joong Won</creator><creator>Sung, Kyung Rim</creator><creator>Park, Sun-Won</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5063-2685</orcidid></search><sort><creationdate>201810</creationdate><title>Patterns of Progressive Ganglion Cell–Inner Plexiform Layer Thinning in Glaucoma Detected by OCT</title><author>Shin, Joong Won ; Sung, Kyung Rim ; Park, Sun-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-a0eafc1107ba01fc8e359da216c6545e3f9c1bce68d9ff8d5d9058dca384f4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Optic Disk - pathology</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Visual Acuity</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Joong Won</creatorcontrib><creatorcontrib>Sung, Kyung Rim</creatorcontrib><creatorcontrib>Park, Sun-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Joong Won</au><au>Sung, Kyung Rim</au><au>Park, Sun-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of Progressive Ganglion Cell–Inner Plexiform Layer Thinning in Glaucoma Detected by OCT</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2018-10</date><risdate>2018</risdate><volume>125</volume><issue>10</issue><spage>1515</spage><epage>1525</epage><pages>1515-1525</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><abstract>To investigate the spatial characteristics and patterns of progressive macular ganglion cell–inner plexiform layer (GCIPL) thinning in glaucomatous eyes assessed by OCT Guided Progression Analysis (GPA).
Longitudinal, retrospective, observational study.
Two hundred ninety-two eyes of 192 patients with primary open-angle glaucoma with a mean follow-up of 6.0 years (range, 3.2–8.1 years) were included.
Macular GCIPL imaging and visual field (VF) examination were performed at 6-month intervals for 3 years or more. Progressive GCIPL thinning was evaluated by a Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) GPA device. Spatial characteristics of progressive GCIPL thinning were assessed by the GCIPL thickness change map. The pattern of progressive GCIPL thinning was evaluated by comparing the baseline GCIPL thickness deviation map and the final GCIPL thickness change map. Visual field progression was determined by Early Manifest Glaucoma Trial criteria and linear regression of the VF index.
Spatial characteristics and patterns of progressive GCIPL thinning.
Seventy-two eyes of 62 participants (24.7% [72/292]) showed progressive GCIPL thinning in the GCIPL thickness change map. Progressive GCIPL thinning was detected most frequently (25.0%) at 2.08 mm from the fovea, and it extended in an arcuate shape in the inferotemporal region (250°–339°). Compared with the baseline GCIPL defects, the progressive GCIPL thinning extended toward the fovea and optic disc. The most common pattern of progressive GCIPL thinning was widening of GCIPL defects (42 eyes [58.3%]), followed by deepening of GCIPL defects (19 eyes [26.4%]) and newly developed GCIPL defects (15 eyes [20.8%]). Visual field progression was accompanied by progressive GCIPL thinning in 41 of 72 eyes (56.9%). Progressive GCIPL thinning preceded (61.0% [25/41]) or occurred concomitantly with (21.9% [9/41]) VF progression.
The use of OCT GPA maps offers an effective approach to evaluate the topographic patterns of progressive GCIPL thinning in glaucomatous eyes. Progression of GCIPL thinning occurred before apparent progression on standard automated perimetry in most glaucomatous eyes. Understanding specific patterns and sequences of macular damage may provide important insights in the monitoring of glaucomatous progression.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29705057</pmid><doi>10.1016/j.ophtha.2018.03.052</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5063-2685</orcidid></addata></record> |
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| ispartof | Ophthalmology (Rochester, Minn.), 2018-10, Vol.125 (10), p.1515-1525 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Disease Progression Female Follow-Up Studies Glaucoma, Open-Angle - diagnosis Humans Intraocular Pressure - physiology Male Middle Aged Nerve Fibers - pathology Optic Disk - pathology Retinal Ganglion Cells - pathology Retrospective Studies Time Factors Tomography, Optical Coherence - methods Visual Acuity Visual Fields - physiology |
| title | Patterns of Progressive Ganglion Cell–Inner Plexiform Layer Thinning in Glaucoma Detected by OCT |
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