Systemic Monotherapy Treatments for Generalized Pustular Psoriasis: A Systematic Review

Generalized pustular psoriasis (GPP) is a rare but serious and difficult to treat cutaneous disease, with high morbidity and mortality rates. Despite the numerous treatment regimens available, the overall quality of evidence-based research is limited with a lack of an algorithmic approach available....

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Veröffentlicht in:Journal of Cutaneous Medicine and Surgery 2018-11, Vol.22 (6), p.591-601
Hauptverfasser: Zhou, Linghong Linda, Georgakopoulos, Jorge R., Ighani, Arvin, Yeung, Jensen
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container_end_page 601
container_issue 6
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container_title Journal of Cutaneous Medicine and Surgery
container_volume 22
creator Zhou, Linghong Linda
Georgakopoulos, Jorge R.
Ighani, Arvin
Yeung, Jensen
description Generalized pustular psoriasis (GPP) is a rare but serious and difficult to treat cutaneous disease, with high morbidity and mortality rates. Despite the numerous treatment regimens available, the overall quality of evidence-based research is limited with a lack of an algorithmic approach available. In this review, we aim to evaluate the current level of evidence regarding the efficacy and safety/tolerability of systemic monotherapies available in the treatment of GPP. A comprehensive MEDLINE, EMBASE, and PubMed search of clinical studies examining systemic monotherapy treatment options for GPP was conducted. In total, 31 studies met eligibility criteria. Described treatment modalities included retinoids, cyclosporine, biologics, and dapsone. Despite the lack of high-quality evidence or a well-accepted treatment algorithm for GPP, systemic retinoids, cyclosporine, biologics, and dapsone are all possible first-line agents, with retinoids being one of the best-supported treatment options and biologics as an emerging therapeutic field with great potential requiring additional data. However, the final choice of treatment should be considered within the unique context of each patient.
doi_str_mv 10.1177/1203475418773358
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subjects Adult
Drug therapy
Evidence
Female
Humans
Male
Middle Aged
Psoriasis
Psoriasis - drug therapy
Skin diseases
Systematic review
title Systemic Monotherapy Treatments for Generalized Pustular Psoriasis: A Systematic Review
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