An in vitro analysis of the rat C6 glioma cells to elucidate the linear alkylbenzene sulfonate induced oxidative stress and consequent G2/M phase cell cycle arrest and cellular apoptosis

An in vitro analysis of the rat C6 glioma cells to elucidate the linear alkylbenzene sulfonate induced oxidative stress and consequent G2/M phase cell cycle arrest and cellular apoptosis

Linear alkylbenzene Sulphonate (LAS) is the anionic surfactant component of globally consumed detergents. Exposure of sub-inhibitory fractions viz., 1/10th (T1), 1/5th (T2), and 1/2.5th (T3) of IC50 for 48 h, of LAS (5 μM, 10 μM, and 20 μM, respectively) to viable C6 glioma cells of rat, besides imp...

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Veröffentlicht in:Chemosphere (Oxford) 2018-08, Vol.205, p.443-451
Hauptverfasser: Shukla, Anubha, Trivedi, Sunil P.
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
C6 glioma cells
Cell cycle arrest
LAS
PARP
ROS
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Zusammenfassung:Linear alkylbenzene Sulphonate (LAS) is the anionic surfactant component of globally consumed detergents. Exposure of sub-inhibitory fractions viz., 1/10th (T1), 1/5th (T2), and 1/2.5th (T3) of IC50 for 48 h, of LAS (5 μM, 10 μM, and 20 μM, respectively) to viable C6 glioma cells of rat, besides imparting morphological alterations leads to gross cytotoxicity. Expression of the damaged DNA coupled with cleaved PARP (p 
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2018.04.127