Effect of TET2 on the pathogenesis of diabetic nephropathy through activation of transforming growth factor β1 expression via DNA demethylation

Transforming growth factor β1 (TGFβ1) plays a pivotal role in the pathogenesis of diabetic nephropathy (DN). However, the mechanism of its expression and activation induced by high glucose (HG) is still unclear. We mainly explored the role of ten-eleven translocation enzyme-2 (TET2) in regulating TG...

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Veröffentlicht in:	Life sciences (1973) 2018-08, Vol.207, p.127-137
Hauptverfasser:	Yang, liling, Zhang, Qian, Wu, Qiong, Wei, Yi, Yu, Jiawei, Mu, Jiao, Zhang, Jun, Zeng, Wei, Feng, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Proliferation CpG Islands Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic nephropathy DNA Methylation DNA-Binding Proteins - metabolism Gene Expression Profiling Gene Expression Regulation Glucose - metabolism Humans Kidney Cortex - metabolism Mesangial cells Mice Phenotype Proto-Oncogene Proteins - metabolism RNA, Small Interfering - metabolism Ten-eleven translocation-2 protein Transforming growth factor beta-1 Transforming Growth Factor beta1 - metabolism
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