Fluorescent Molecular Rotors for Viscosity Sensors
Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π‐conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing...
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| Veröffentlicht in: | Chemistry : a European journal 2018-09, Vol.24 (52), p.13706-13718 |
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| container_title | Chemistry : a European journal |
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| creator | Lee, Seung‐Chul Heo, Jeongyun Woo, Hee Chul Lee, Ji‐Ah Seo, Young Hun Lee, Chang‐Lyoul Kim, Sehoon Kwon, O‐Pil |
| description | Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π‐conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push–pull type π‐conjugated chromophores, meso‐phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity‐responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity‐contrast trade‐off) and their biological and microfluidic applications are also discussed.
Spinning around: This minireview discusses recently developed fluorescent molecular rotors (FMRs), which act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In addition, the mechanism of viscosity‐responsive fluorescence, design strategy of FMRs for addressing remarkable issues, and their various biological and microfluidic applications, are also discussed. |
| doi_str_mv | 10.1002/chem.201801389 |
| format | Article |
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Spinning around: This minireview discusses recently developed fluorescent molecular rotors (FMRs), which act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In addition, the mechanism of viscosity‐responsive fluorescence, design strategy of FMRs for addressing remarkable issues, and their various biological and microfluidic applications, are also discussed.</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201801389</identifier><identifier>PMID: 29700889</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Chemistry ; Chromophores ; Derivatives ; Fluorescence ; fluorescence dynamics ; fluorescent molecular rotors ; microviscosity ; molecular rotors ; Organelles ; Rotors ; Sensors ; Viscosity ; viscosity sensors</subject><ispartof>Chemistry : a European journal, 2018-09, Vol.24 (52), p.13706-13718</ispartof><rights>2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4769-b6564ef485624cc3a0f6ed85ce09f525f11536f51c0b12dab98bfff7cd92b99b3</citedby><cites>FETCH-LOGICAL-c4769-b6564ef485624cc3a0f6ed85ce09f525f11536f51c0b12dab98bfff7cd92b99b3</cites><orcidid>0000-0002-7964-687X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.201801389$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.201801389$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29700889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Seung‐Chul</creatorcontrib><creatorcontrib>Heo, Jeongyun</creatorcontrib><creatorcontrib>Woo, Hee Chul</creatorcontrib><creatorcontrib>Lee, Ji‐Ah</creatorcontrib><creatorcontrib>Seo, Young Hun</creatorcontrib><creatorcontrib>Lee, Chang‐Lyoul</creatorcontrib><creatorcontrib>Kim, Sehoon</creatorcontrib><creatorcontrib>Kwon, O‐Pil</creatorcontrib><title>Fluorescent Molecular Rotors for Viscosity Sensors</title><title>Chemistry : a European journal</title><addtitle>Chemistry</addtitle><description>Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π‐conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push–pull type π‐conjugated chromophores, meso‐phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity‐responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity‐contrast trade‐off) and their biological and microfluidic applications are also discussed.
Spinning around: This minireview discusses recently developed fluorescent molecular rotors (FMRs), which act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In addition, the mechanism of viscosity‐responsive fluorescence, design strategy of FMRs for addressing remarkable issues, and their various biological and microfluidic applications, are also discussed.</description><subject>Chemistry</subject><subject>Chromophores</subject><subject>Derivatives</subject><subject>Fluorescence</subject><subject>fluorescence dynamics</subject><subject>fluorescent molecular rotors</subject><subject>microviscosity</subject><subject>molecular rotors</subject><subject>Organelles</subject><subject>Rotors</subject><subject>Sensors</subject><subject>Viscosity</subject><subject>viscosity sensors</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkM9LwzAUgIMobk6vHqXgxUvnS9KkyVHG5oSJ4K9raNMEO9plJi2y_96MzQlePD14fO_j8SF0iWGMAcit_jDtmAAWgKmQR2iIGcEpzTk7RkOQWZ5yRuUAnYWwBADJKT1FAyJzACHkEJFZ0ztvgjarLnl0jdF9U_jk2XXOh8Q6n7zXQbtQd5vkxaxC3J6jE1s0wVzs5wi9zaavk3m6eLp_mNwtUp3lXKYlZzwzNhOMk0xrWoDlphJMG5CWEWYxZpRbhjWUmFRFKUVprc11JUkpZUlH6GbnXXv32ZvQqTa-YpqmWBnXB0WAkgznPOMRvf6DLl3vV_E7RTCOjGRERGq8o7R3IXhj1drXbeE3CoPa1lTbmupQMx5c7bV92ZrqgP_ki4DcAV91Yzb_6NRkPn38lX8DF8KAKw</recordid><startdate>20180918</startdate><enddate>20180918</enddate><creator>Lee, Seung‐Chul</creator><creator>Heo, Jeongyun</creator><creator>Woo, Hee Chul</creator><creator>Lee, Ji‐Ah</creator><creator>Seo, Young Hun</creator><creator>Lee, Chang‐Lyoul</creator><creator>Kim, Sehoon</creator><creator>Kwon, O‐Pil</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7964-687X</orcidid></search><sort><creationdate>20180918</creationdate><title>Fluorescent Molecular Rotors for Viscosity Sensors</title><author>Lee, Seung‐Chul ; Heo, Jeongyun ; Woo, Hee Chul ; Lee, Ji‐Ah ; Seo, Young Hun ; Lee, Chang‐Lyoul ; Kim, Sehoon ; Kwon, O‐Pil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4769-b6564ef485624cc3a0f6ed85ce09f525f11536f51c0b12dab98bfff7cd92b99b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Chemistry</topic><topic>Chromophores</topic><topic>Derivatives</topic><topic>Fluorescence</topic><topic>fluorescence dynamics</topic><topic>fluorescent molecular rotors</topic><topic>microviscosity</topic><topic>molecular rotors</topic><topic>Organelles</topic><topic>Rotors</topic><topic>Sensors</topic><topic>Viscosity</topic><topic>viscosity sensors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Seung‐Chul</creatorcontrib><creatorcontrib>Heo, Jeongyun</creatorcontrib><creatorcontrib>Woo, Hee Chul</creatorcontrib><creatorcontrib>Lee, Ji‐Ah</creatorcontrib><creatorcontrib>Seo, Young Hun</creatorcontrib><creatorcontrib>Lee, Chang‐Lyoul</creatorcontrib><creatorcontrib>Kim, Sehoon</creatorcontrib><creatorcontrib>Kwon, O‐Pil</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seung‐Chul</au><au>Heo, Jeongyun</au><au>Woo, Hee Chul</au><au>Lee, Ji‐Ah</au><au>Seo, Young Hun</au><au>Lee, Chang‐Lyoul</au><au>Kim, Sehoon</au><au>Kwon, O‐Pil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescent Molecular Rotors for Viscosity Sensors</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chemistry</addtitle><date>2018-09-18</date><risdate>2018</risdate><volume>24</volume><issue>52</issue><spage>13706</spage><epage>13718</epage><pages>13706-13718</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><abstract>Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π‐conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push–pull type π‐conjugated chromophores, meso‐phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity‐responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity‐contrast trade‐off) and their biological and microfluidic applications are also discussed.
Spinning around: This minireview discusses recently developed fluorescent molecular rotors (FMRs), which act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In addition, the mechanism of viscosity‐responsive fluorescence, design strategy of FMRs for addressing remarkable issues, and their various biological and microfluidic applications, are also discussed.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29700889</pmid><doi>10.1002/chem.201801389</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-7964-687X</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Chemistry Chromophores Derivatives Fluorescence fluorescence dynamics fluorescent molecular rotors microviscosity molecular rotors Organelles Rotors Sensors Viscosity viscosity sensors |
| title | Fluorescent Molecular Rotors for Viscosity Sensors |
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