$Clonal T cell receptor gene rearrangements in coeliac disease: implications for diagnosing refractory coeliac disease$

Clonal T cell receptor gene rearrangements in coeliac disease: implications for diagnosing refractory coeliac disease

AimsRefractory coeliac disease type II (RCDII), a rare complication of coeliac disease (CD) associated with high morbidity, requires identification of a clonal population of phenotypically aberrant intraepithelial lymphocytes (IELs) for diagnosis. However, data regarding the frequency and significan...

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Veröffentlicht in:	Journal of clinical pathology 2018-09, Vol.71 (9), p.825-831
Hauptverfasser:	Hussein, Shafinaz, Gindin, Tatyana, Lagana, Stephen M, Arguelles-Grande, Carolina, Krishnareddy, Suneeta, Alobeid, Bachir, Lewis, Suzanne K, Mansukhani, Mahesh M, Green, Peter H R, Bhagat, Govind
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biopsy Capillary electrophoresis Celiac disease Celiac Disease - diagnosis Celiac Disease - diet therapy Celiac Disease - genetics Celiac Disease - immunology Classification Clone Cells Diet, Gluten-Free Female Flow Cytometry Gastroenterology Gene Rearrangement Genes, T-Cell Receptor Genetic Predisposition to Disease Genotype & phenotype Gluten Histology Histopathology Humans Immunoglobulins Immunophenotyping - methods Intestine, Small - immunology Intestine, Small - pathology Intraepithelial Lymphocytes - immunology Intraepithelial Lymphocytes - pathology Lymphocytes Lymphoma Male Medical diagnosis Middle Aged Phenotype Polymerase Chain Reaction Predictive Value of Tests T cell receptors Young Adult
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