Impaired Bioenergetics in Mutant Mitochondrial DNA Determines Cell Fate During Seizure-Like Activity

Mutations in genes affecting mitochondrial proteins are increasingly recognised in patients with epilepsy, but the factors determining cell fate during seizure activity in these mutations remain unknown. Fluorescent dye imaging techniques were applied to fibroblast cell lines from patients suffering...

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Veröffentlicht in:	Molecular neurobiology 2019, Vol.56 (1), p.321-334
Hauptverfasser:	Kovac, Stjepana, Preza, Elisavet, Houlden, Henry, Walker, Matthew C., Abramov, Andrey Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Bioenergetics Biomedical and Life Sciences Biomedicine Calcium (intracellular) Calcium - metabolism Calcium Signaling Calcium signalling Cell Biology Cell death Cell fate Cell Line Cell Lineage - genetics Cell lines Cell Respiration Convulsions & seizures DNA, Mitochondrial - genetics Electron transport Energy Metabolism Epilepsy Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Flash photolysis Fluorescent indicators Genomes Humans Membrane potential Membrane Potential, Mitochondrial Mitochondria - metabolism Mitochondrial DNA Mutation Mutation - genetics NAD - metabolism NADH Neurobiology Neurology Neurosciences Oxidation-Reduction Photolysis Proteins Seizures Seizures - genetics Seizures - pathology
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