PA28γ acts as a dual regulator of IL-6 and CCL2 and contributes to tumor angiogenesis in oral squamous cell carcinoma

PA28γ promotes tumor development and progression and is suggested to play a role in tumor angiogenesis, but the molecular mechanisms have not been investigated. Here, we found that PA28γ enhanced the ability of OSCC cells to promote the migration, invasion, and tube formation of HUVECs and promoted...

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Veröffentlicht in:	Cancer letters 2018-08, Vol.428, p.192-200
Hauptverfasser:	Liu, Sai, Liu, Dongjuan, Zeng, Xin, Wang, Jiongke, Liu, Jiajia, Cheng, Junxin, Lei, Kexin, Bai, Hetian, Ji, Ning, Zhou, Min, Jiang, Lu, Dan, Hongxia, Li, Jing, Chen, Qianming
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Angiogenesis Animal models Cancer CCL2 Cell migration Danio rerio Deoxyribonucleic acid DNA Embryos Experiments Gene expression IL-6 Interleukin 6 Laboratories Medical prognosis Metastasis Migration Molecular chains Molecular modelling Monocyte chemoattractant protein 1 NF-κB protein Oral cancer Oral squamous cell carcinoma OSCC PA28γ Secretion Squamous cell carcinoma Stains & staining Stat3 protein Therapeutic applications Tumor angiogenesis Tumors Xenografts
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