Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues

The plant-derived, diterpenoid 7-keto-sempervirol was recently reported to display moderate activity against larval stages of Schistosoma mansoni (IC50 = 19.1 μM) and Fasciola hepatica (IC50 = 17.7 μM), two related parasitic blood and liver flukes responsible for the neglected tropical diseases schi...

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Veröffentlicht in:European journal of medicinal chemistry 2018-05, Vol.152, p.87-100
Hauptverfasser: Crusco, Alessandra, Bordoni, Cinzia, Chakroborty, Anand, Whatley, Kezia C.L., Whiteland, Helen, Westwell, Andrew D., Hoffmann, Karl F.
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Sprache:eng
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