Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited
Fibrosis is a common complication and contributor to the morbidity and mortality of a number of acute or chronic lung diseases. Among these pathologies, the most pernicious is idiopathic pulmonary fibrosis (IPF). IPF is characterized by a relentless, progressive accumulation of fibrotic tissue leadi...
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| Veröffentlicht in: | American journal of respiratory cell and molecular biology 2018-08, Vol.59 (2), p.137-138 |
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| container_title | American journal of respiratory cell and molecular biology |
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| creator | Le Saux, Claude Jourdan Chapman, Harold A |
| description | Fibrosis is a common complication and contributor to the morbidity and mortality of a number of acute or chronic lung diseases. Among these pathologies, the most pernicious is idiopathic pulmonary fibrosis (IPF). IPF is characterized by a relentless, progressive accumulation of fibrotic tissue leading to irreversible destruction of lung architecture. As a result, patients with IPF, for whom no curative treatment option is available except for lung transplantation, will die of respiratory failure, with a median survival of 3-5 years from diagnosis. Finally, this study also brings to light some thought-challenging questions related to inflammation and its underlying contribution to IPF. Inflammation has not been considered critical to IPF initiation or progression. |
| doi_str_mv | 10.1165/rcmb.2018-0083ED |
| format | Article |
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Among these pathologies, the most pernicious is idiopathic pulmonary fibrosis (IPF). IPF is characterized by a relentless, progressive accumulation of fibrotic tissue leading to irreversible destruction of lung architecture. As a result, patients with IPF, for whom no curative treatment option is available except for lung transplantation, will die of respiratory failure, with a median survival of 3-5 years from diagnosis. Finally, this study also brings to light some thought-challenging questions related to inflammation and its underlying contribution to IPF. Inflammation has not been considered critical to IPF initiation or progression.</description><identifier>ISSN: 1044-1549</identifier><identifier>EISSN: 1535-4989</identifier><identifier>DOI: 10.1165/rcmb.2018-0083ED</identifier><identifier>PMID: 29698615</identifier><language>eng</language><publisher>United States: American Thoracic Society</publisher><subject>Alveolar Epithelial Cells ; Apoptosis ; Cell Death ; Cytokines ; Deoxyribonucleic acid ; Disease ; DNA ; Endoplasmic reticulum ; Fibrosis ; Gangrene ; Humans ; Idiopathic Pulmonary Fibrosis ; Inflammation ; Influenza ; Kinases ; Lung diseases ; Lung transplantation ; Lungs ; Mitochondria ; Mitochondrial DNA ; Morbidity ; Pathogenesis ; Phosphorylation ; Proteins ; Pulmonary fibrosis ; Senescence ; Studies ; Viral infections</subject><ispartof>American journal of respiratory cell and molecular biology, 2018-08, Vol.59 (2), p.137-138</ispartof><rights>Copyright American Thoracic Society Aug 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-16f14980c588b01dd7a796ba30a5f09588bee81a61289885b6a06bb6dba033a53</citedby><cites>FETCH-LOGICAL-c327t-16f14980c588b01dd7a796ba30a5f09588bee81a61289885b6a06bb6dba033a53</cites><orcidid>0000-0002-6041-2870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29698615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Saux, Claude Jourdan</creatorcontrib><creatorcontrib>Chapman, Harold A</creatorcontrib><title>Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited</title><title>American journal of respiratory cell and molecular biology</title><addtitle>Am J Respir Cell Mol Biol</addtitle><description>Fibrosis is a common complication and contributor to the morbidity and mortality of a number of acute or chronic lung diseases. Among these pathologies, the most pernicious is idiopathic pulmonary fibrosis (IPF). IPF is characterized by a relentless, progressive accumulation of fibrotic tissue leading to irreversible destruction of lung architecture. As a result, patients with IPF, for whom no curative treatment option is available except for lung transplantation, will die of respiratory failure, with a median survival of 3-5 years from diagnosis. Finally, this study also brings to light some thought-challenging questions related to inflammation and its underlying contribution to IPF. 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| source | Journals@Ovid Ovid Autoload; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alveolar Epithelial Cells Apoptosis Cell Death Cytokines Deoxyribonucleic acid Disease DNA Endoplasmic reticulum Fibrosis Gangrene Humans Idiopathic Pulmonary Fibrosis Inflammation Influenza Kinases Lung diseases Lung transplantation Lungs Mitochondria Mitochondrial DNA Morbidity Pathogenesis Phosphorylation Proteins Pulmonary fibrosis Senescence Studies Viral infections |
| title | Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited |
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