Heme Oxygenase-1 Inhibits the Expression of Adhesion Molecules Associated with Endothelial Cell Activation via Inhibition of NF-κB RelA Phosphorylation at Serine 276

Heme oxygenase-1 (HO-1; encoded by the Hmox1 gene) catalyzes the degradation of free heme into biliverdin, via a reaction that releases iron (Fe) and carbon monoxide. We report that HO-1 down-regulates the proinflammatory phenotype associated with endothelial cell (EC) activation by reducing intrace...

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Veröffentlicht in:	The Journal of immunology (1950) 2007-12, Vol.179 (11), p.7840-7851
Hauptverfasser:	Seldon, Mark P., Silva, Gabriela, Pejanovic, Nadja, Larsen, Rasmus, Gregoire, Isabel Pombo, Filipe, Josina, Anrather, Josef, Soares, Miguel P.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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