The Role of Distal S6 Hydrophobic Residues in the Voltage-dependent Gating of Ca sub(V)2.3 Channels

The hydrophobic locus VAVIM is conserved in the S6 transmembrane segment of domain IV (IVS6) in Ca sub(V)1 and Ca sub(V)2 families. Herein we show that glycine substitution of the VAVIM motif in Ca sub(V)2.3 produced whole cell currents with inactivation kinetics that were either slower (A1719G appr...

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Veröffentlicht in:	The Journal of biological chemistry 2007-09, Vol.282 (38), p.27944-27952
Hauptverfasser:	Raybaud, Alexandra, Baspinar, Ebru-Eylem, Dionne, Francois, Dodier, Yolaine, Sauve, Remy, Parent, Lucie
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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