Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats
Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-partic...
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description | Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 and nano vitamin E.
Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10 mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH), triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and antioxidants “reduced glutathione (GSH) and superoxide dismutase (SOD)” were measured. Additionally quadriceps muscles and liver tissues were used for histopathological examination.
The antihyperlipidemic effect of statins was not altered when formulated as nanoparticles; albeit the former showed a prominent reduction in the liver and muscle enzymes and histopathological alterations together with a marked decline in the oxidative stress as compared to the free particulate form. These results were augmented when atorvastatin was combined with CoQ10 and/or Vit.E.
Nanoparticulate formulation alleviated the statins induced liver and muscle damage especially when combined with CoQ10 and/or Vit.E. |
doi_str_mv | 10.1016/j.lfs.2018.04.034 |
format | Article |
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Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10 mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH), triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and antioxidants “reduced glutathione (GSH) and superoxide dismutase (SOD)” were measured. Additionally quadriceps muscles and liver tissues were used for histopathological examination.
The antihyperlipidemic effect of statins was not altered when formulated as nanoparticles; albeit the former showed a prominent reduction in the liver and muscle enzymes and histopathological alterations together with a marked decline in the oxidative stress as compared to the free particulate form. These results were augmented when atorvastatin was combined with CoQ10 and/or Vit.E.
Nanoparticulate formulation alleviated the statins induced liver and muscle damage especially when combined with CoQ10 and/or Vit.E.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2018.04.034</identifier><identifier>PMID: 29694831</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Alanine ; Alkaline phosphatase ; Antioxidants ; Atorvastatin ; Cardiovascular diseases ; Cholesterol ; Coenzyme Q10 ; CoQ 10 ; Creatine ; Creatine kinase ; Density ; Diet ; Glutathione ; Heart diseases ; High density lipoprotein ; High fat diet ; Lipoproteins ; Liver ; Liver damage ; Liver diseases ; Low density lipoprotein ; Malondialdehyde ; Muscles ; Myalgia ; Myopathy ; Nanoparticles ; Nanoparticulate ; Oxidative stress ; Particulates ; Quadriceps muscle ; Rats ; Rodents ; Statins ; Superoxide dismutase ; Tocopherol ; Transaminases ; Triglycerides ; Vitamin E</subject><ispartof>Life sciences (1973), 2018-06, Vol.203, p.129-140</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2017. Published by Elsevier Inc.</rights><rights>Copyright Elsevier BV Jun 15, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-d2dbdafd1b541aeb6cb6b9f07d7c2c3fd05be02c3dec85b0e0f5ded3a7c9f7a83</citedby><cites>FETCH-LOGICAL-c381t-d2dbdafd1b541aeb6cb6b9f07d7c2c3fd05be02c3dec85b0e0f5ded3a7c9f7a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2018.04.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29694831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farrag, S.M.</creatorcontrib><creatorcontrib>Hamzawy, M.A.</creatorcontrib><creatorcontrib>El-Yamany, M.F.</creatorcontrib><creatorcontrib>Saad, M.A.</creatorcontrib><creatorcontrib>Nassar, N.N.</creatorcontrib><title>Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 and nano vitamin E.
Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10 mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH), triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and antioxidants “reduced glutathione (GSH) and superoxide dismutase (SOD)” were measured. Additionally quadriceps muscles and liver tissues were used for histopathological examination.
The antihyperlipidemic effect of statins was not altered when formulated as nanoparticles; albeit the former showed a prominent reduction in the liver and muscle enzymes and histopathological alterations together with a marked decline in the oxidative stress as compared to the free particulate form. These results were augmented when atorvastatin was combined with CoQ10 and/or Vit.E.
Nanoparticulate formulation alleviated the statins induced liver and muscle damage especially when combined with CoQ10 and/or Vit.E.</description><subject>Alanine</subject><subject>Alkaline phosphatase</subject><subject>Antioxidants</subject><subject>Atorvastatin</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol</subject><subject>Coenzyme Q10</subject><subject>CoQ 10</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Density</subject><subject>Diet</subject><subject>Glutathione</subject><subject>Heart diseases</subject><subject>High density lipoprotein</subject><subject>High fat diet</subject><subject>Lipoproteins</subject><subject>Liver</subject><subject>Liver damage</subject><subject>Liver diseases</subject><subject>Low density lipoprotein</subject><subject>Malondialdehyde</subject><subject>Muscles</subject><subject>Myalgia</subject><subject>Myopathy</subject><subject>Nanoparticles</subject><subject>Nanoparticulate</subject><subject>Oxidative stress</subject><subject>Particulates</subject><subject>Quadriceps muscle</subject><subject>Rats</subject><subject>Rodents</subject><subject>Statins</subject><subject>Superoxide dismutase</subject><subject>Tocopherol</subject><subject>Transaminases</subject><subject>Triglycerides</subject><subject>Vitamin E</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kc2KFTEQhRtRnOvoA7iRgBs33VPp9C-uhmH8gQERdB3SSYWbSzppk_Qdrk8yj2vaO7pwIQRSCd85VdQpitcUKgq0uzpUVseqBjpU0FTAmifFjg79WELH6NNiB1A3JauhvShexHgAgLbt2fPioh67sRkY3RUP18mHo4hJJONIPk44Xy4iJCNXKxIS7cO8VcY7Iqb8E8m8RmmRCKeINUcMRGhtjfyN3O_REemFxShRkXuT9vmJ7udpRvKVwqa68oEcTRJz7ne7Nd2fFgzWLEbhbCQJIsWXxTMtbMRXj_dl8f3D7bebT-Xdl4-fb67vSskGmkpVq0kJrejUNlTg1Mmpm0YNveplLZlW0E4IuVIoh3YCBN0qVEz0ctS9GNhl8e7suwT_Y8WY-Gzy5NYKh36NvAZGm5r2TZ3Rt_-gB78Gl6fLVE8ZNF3HMkXPlAw-xoCaL8HMIpw4Bb7Fxg88x8a32Dg0PMeWNW8enddpRvVX8SenDLw_A5hXcTQYeJQGXd6wCSgTV978x_4XN-ysew</recordid><startdate>20180615</startdate><enddate>20180615</enddate><creator>Farrag, S.M.</creator><creator>Hamzawy, M.A.</creator><creator>El-Yamany, M.F.</creator><creator>Saad, M.A.</creator><creator>Nassar, N.N.</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180615</creationdate><title>Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats</title><author>Farrag, S.M. ; Hamzawy, M.A. ; El-Yamany, M.F. ; Saad, M.A. ; Nassar, N.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-d2dbdafd1b541aeb6cb6b9f07d7c2c3fd05be02c3dec85b0e0f5ded3a7c9f7a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alanine</topic><topic>Alkaline phosphatase</topic><topic>Antioxidants</topic><topic>Atorvastatin</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol</topic><topic>Coenzyme Q10</topic><topic>CoQ 10</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Density</topic><topic>Diet</topic><topic>Glutathione</topic><topic>Heart diseases</topic><topic>High density lipoprotein</topic><topic>High fat diet</topic><topic>Lipoproteins</topic><topic>Liver</topic><topic>Liver damage</topic><topic>Liver diseases</topic><topic>Low density lipoprotein</topic><topic>Malondialdehyde</topic><topic>Muscles</topic><topic>Myalgia</topic><topic>Myopathy</topic><topic>Nanoparticles</topic><topic>Nanoparticulate</topic><topic>Oxidative stress</topic><topic>Particulates</topic><topic>Quadriceps muscle</topic><topic>Rats</topic><topic>Rodents</topic><topic>Statins</topic><topic>Superoxide dismutase</topic><topic>Tocopherol</topic><topic>Transaminases</topic><topic>Triglycerides</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farrag, S.M.</creatorcontrib><creatorcontrib>Hamzawy, M.A.</creatorcontrib><creatorcontrib>El-Yamany, M.F.</creatorcontrib><creatorcontrib>Saad, M.A.</creatorcontrib><creatorcontrib>Nassar, N.N.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farrag, S.M.</au><au>Hamzawy, M.A.</au><au>El-Yamany, M.F.</au><au>Saad, M.A.</au><au>Nassar, N.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2018-06-15</date><risdate>2018</risdate><volume>203</volume><spage>129</spage><epage>140</epage><pages>129-140</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 and nano vitamin E.
Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10 mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH), triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and antioxidants “reduced glutathione (GSH) and superoxide dismutase (SOD)” were measured. Additionally quadriceps muscles and liver tissues were used for histopathological examination.
The antihyperlipidemic effect of statins was not altered when formulated as nanoparticles; albeit the former showed a prominent reduction in the liver and muscle enzymes and histopathological alterations together with a marked decline in the oxidative stress as compared to the free particulate form. These results were augmented when atorvastatin was combined with CoQ10 and/or Vit.E.
Nanoparticulate formulation alleviated the statins induced liver and muscle damage especially when combined with CoQ10 and/or Vit.E.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>29694831</pmid><doi>10.1016/j.lfs.2018.04.034</doi><tpages>12</tpages></addata></record> |
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subjects | Alanine Alkaline phosphatase Antioxidants Atorvastatin Cardiovascular diseases Cholesterol Coenzyme Q10 CoQ 10 Creatine Creatine kinase Density Diet Glutathione Heart diseases High density lipoprotein High fat diet Lipoproteins Liver Liver damage Liver diseases Low density lipoprotein Malondialdehyde Muscles Myalgia Myopathy Nanoparticles Nanoparticulate Oxidative stress Particulates Quadriceps muscle Rats Rodents Statins Superoxide dismutase Tocopherol Transaminases Triglycerides Vitamin E |
title | Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats |
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