Mortality After Pediatric Arterial Ischemic Stroke
Cerebrovascular disease is among the top 10 causes of death in US children, but risk factors for mortality are poorly understood. Within an international registry, we identify predictors of in-hospital mortality after pediatric arterial ischemic stroke (AIS). Neonates (0-28 days) and children (29 da...
Gespeichert in:
| Veröffentlicht in: | Pediatrics (Evanston) 2018-05, Vol.141 (5), p.1 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | 1 |
| container_title | Pediatrics (Evanston) |
| container_volume | 141 |
| creator | Beslow, Lauren A Dowling, Michael M Hassanein, Sahar M A Lynch, John K Zafeiriou, Dimitrios Sun, Lisa R Kopyta, Ilona Titomanlio, Luigi Kolk, Anneli Chan, Anthony Biller, Jose Grabowski, Eric F Abdalla, Abdalla A Mackay, Mark T deVeber, Gabrielle |
| description | Cerebrovascular disease is among the top 10 causes of death in US children, but risk factors for mortality are poorly understood. Within an international registry, we identify predictors of in-hospital mortality after pediatric arterial ischemic stroke (AIS).
Neonates (0-28 days) and children (29 days- |
| doi_str_mv | 10.1542/peds.2017-4146 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2031416413</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A538959003</galeid><sourcerecordid>A538959003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c401t-84481aaab5b0ecc790607fca9619706515bc7f5a367ab2d79d73f978ce60bd2a3</originalsourceid><addsrcrecordid>eNpdkE1LAzEQhoMotlavHqXgxcvWyddmcyzFj4JSQT2HbHa2bt12a5KC_femtHrwNMzwzPDOQ8glhRGVgt2usQojBlRlgor8iPQp6CITTMlj0gfgNBMAskfOQlgAgJCKnZIe07mWspB9wp47H23bxO1wXEf0wxesGht944Zjn_rGtsNpcB-4TJPX6LtPPCcntW0DXhzqgLzf371NHrOn2cN0Mn7KnAAas0KIglprS1kCOqc05KBqZ3VOtYJcUlk6VUvLc2VLVildKV5rVTjMoayY5QNys7-79t3XBkM0yyY4bFu7wm4TDEvfCZoLyhN6_Q9ddBu_SukSVWjFuVY6UdmemtsWTbNy3Srid3Rd2-IcTQo_mZmx5IWWOqlL_GjPO9-F4LE2a98srd8aCmZn3-zsm519s7OfFq4OMTblEqs__Fc3_wFrR32X</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2089733979</pqid></control><display><type>article</type><title>Mortality After Pediatric Arterial Ischemic Stroke</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Beslow, Lauren A ; Dowling, Michael M ; Hassanein, Sahar M A ; Lynch, John K ; Zafeiriou, Dimitrios ; Sun, Lisa R ; Kopyta, Ilona ; Titomanlio, Luigi ; Kolk, Anneli ; Chan, Anthony ; Biller, Jose ; Grabowski, Eric F ; Abdalla, Abdalla A ; Mackay, Mark T ; deVeber, Gabrielle</creator><creatorcontrib>Beslow, Lauren A ; Dowling, Michael M ; Hassanein, Sahar M A ; Lynch, John K ; Zafeiriou, Dimitrios ; Sun, Lisa R ; Kopyta, Ilona ; Titomanlio, Luigi ; Kolk, Anneli ; Chan, Anthony ; Biller, Jose ; Grabowski, Eric F ; Abdalla, Abdalla A ; Mackay, Mark T ; deVeber, Gabrielle ; International Pediatric Stroke Study Investigators ; on behalf of the International Pediatric Stroke Study Investigators</creatorcontrib><description>Cerebrovascular disease is among the top 10 causes of death in US children, but risk factors for mortality are poorly understood. Within an international registry, we identify predictors of in-hospital mortality after pediatric arterial ischemic stroke (AIS).
Neonates (0-28 days) and children (29 days-<19 years) with AIS were enrolled from January 2003 to July 2014 in a multinational stroke registry. Death during hospitalization and cause of death were ascertained from medical records. Logistic regression was used to analyze associations between risk factors and in-hospital mortality.
Fourteen of 915 neonates (1.5%) and 70 of 2273 children (3.1%) died during hospitalization. Of 48 cases with reported causes of death, 31 (64.6%) were stroke-related, with remaining deaths attributed to medical disease. In multivariable analysis, congenital heart disease (odds ratio [OR]: 3.88; 95% confidence interval [CI]: 1.23-12.29;
= .021), posterior plus anterior circulation stroke (OR: 5.36; 95% CI: 1.70-16.85;
= .004), and stroke presentation without seizures (OR: 3.95; 95% CI: 1.26-12.37;
= .019) were associated with in-hospital mortality for neonates. Hispanic ethnicity (OR: 3.12; 95% CI: 1.56-6.24;
= .001), congenital heart disease (OR: 3.14; 95% CI: 1.75-5.61;
< .001), and posterior plus anterior circulation stroke (OR: 2.71; 95% CI: 1.40-5.25;
= .003) were associated with in-hospital mortality for children.
In-hospital mortality occurred in 2.6% of pediatric AIS cases. Most deaths were attributable to stroke. Risk factors for in-hospital mortality included congenital heart disease and posterior plus anterior circulation stroke. Presentation without seizures and Hispanic ethnicity were also associated with mortality for neonates and children, respectively. Awareness and study of risk factors for mortality represent opportunities to increase survival.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2017-4146</identifier><identifier>PMID: 29695585</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Analysis ; Child health ; Child mortality ; Children ; Coronary artery disease ; Death ; Ethnicity ; Fatalities ; Health aspects ; Health risks ; Heart diseases ; Hospitalization ; Ischemia ; Medical records ; Minority & ethnic groups ; Mortality ; Neonates ; Patient outcomes ; Pediatrics ; Regression analysis ; Risk factors ; Seizures ; Statistics ; Stroke ; Stroke (Disease) ; United States</subject><ispartof>Pediatrics (Evanston), 2018-05, Vol.141 (5), p.1</ispartof><rights>Copyright © 2018 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics May 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-84481aaab5b0ecc790607fca9619706515bc7f5a367ab2d79d73f978ce60bd2a3</citedby><cites>FETCH-LOGICAL-c401t-84481aaab5b0ecc790607fca9619706515bc7f5a367ab2d79d73f978ce60bd2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29695585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beslow, Lauren A</creatorcontrib><creatorcontrib>Dowling, Michael M</creatorcontrib><creatorcontrib>Hassanein, Sahar M A</creatorcontrib><creatorcontrib>Lynch, John K</creatorcontrib><creatorcontrib>Zafeiriou, Dimitrios</creatorcontrib><creatorcontrib>Sun, Lisa R</creatorcontrib><creatorcontrib>Kopyta, Ilona</creatorcontrib><creatorcontrib>Titomanlio, Luigi</creatorcontrib><creatorcontrib>Kolk, Anneli</creatorcontrib><creatorcontrib>Chan, Anthony</creatorcontrib><creatorcontrib>Biller, Jose</creatorcontrib><creatorcontrib>Grabowski, Eric F</creatorcontrib><creatorcontrib>Abdalla, Abdalla A</creatorcontrib><creatorcontrib>Mackay, Mark T</creatorcontrib><creatorcontrib>deVeber, Gabrielle</creatorcontrib><creatorcontrib>International Pediatric Stroke Study Investigators</creatorcontrib><creatorcontrib>on behalf of the International Pediatric Stroke Study Investigators</creatorcontrib><title>Mortality After Pediatric Arterial Ischemic Stroke</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Cerebrovascular disease is among the top 10 causes of death in US children, but risk factors for mortality are poorly understood. Within an international registry, we identify predictors of in-hospital mortality after pediatric arterial ischemic stroke (AIS).
Neonates (0-28 days) and children (29 days-<19 years) with AIS were enrolled from January 2003 to July 2014 in a multinational stroke registry. Death during hospitalization and cause of death were ascertained from medical records. Logistic regression was used to analyze associations between risk factors and in-hospital mortality.
Fourteen of 915 neonates (1.5%) and 70 of 2273 children (3.1%) died during hospitalization. Of 48 cases with reported causes of death, 31 (64.6%) were stroke-related, with remaining deaths attributed to medical disease. In multivariable analysis, congenital heart disease (odds ratio [OR]: 3.88; 95% confidence interval [CI]: 1.23-12.29;
= .021), posterior plus anterior circulation stroke (OR: 5.36; 95% CI: 1.70-16.85;
= .004), and stroke presentation without seizures (OR: 3.95; 95% CI: 1.26-12.37;
= .019) were associated with in-hospital mortality for neonates. Hispanic ethnicity (OR: 3.12; 95% CI: 1.56-6.24;
= .001), congenital heart disease (OR: 3.14; 95% CI: 1.75-5.61;
< .001), and posterior plus anterior circulation stroke (OR: 2.71; 95% CI: 1.40-5.25;
= .003) were associated with in-hospital mortality for children.
In-hospital mortality occurred in 2.6% of pediatric AIS cases. Most deaths were attributable to stroke. Risk factors for in-hospital mortality included congenital heart disease and posterior plus anterior circulation stroke. Presentation without seizures and Hispanic ethnicity were also associated with mortality for neonates and children, respectively. Awareness and study of risk factors for mortality represent opportunities to increase survival.</description><subject>Analysis</subject><subject>Child health</subject><subject>Child mortality</subject><subject>Children</subject><subject>Coronary artery disease</subject><subject>Death</subject><subject>Ethnicity</subject><subject>Fatalities</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Heart diseases</subject><subject>Hospitalization</subject><subject>Ischemia</subject><subject>Medical records</subject><subject>Minority & ethnic groups</subject><subject>Mortality</subject><subject>Neonates</subject><subject>Patient outcomes</subject><subject>Pediatrics</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Seizures</subject><subject>Statistics</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><subject>United States</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkE1LAzEQhoMotlavHqXgxcvWyddmcyzFj4JSQT2HbHa2bt12a5KC_femtHrwNMzwzPDOQ8glhRGVgt2usQojBlRlgor8iPQp6CITTMlj0gfgNBMAskfOQlgAgJCKnZIe07mWspB9wp47H23bxO1wXEf0wxesGht944Zjn_rGtsNpcB-4TJPX6LtPPCcntW0DXhzqgLzf371NHrOn2cN0Mn7KnAAas0KIglprS1kCOqc05KBqZ3VOtYJcUlk6VUvLc2VLVildKV5rVTjMoayY5QNys7-79t3XBkM0yyY4bFu7wm4TDEvfCZoLyhN6_Q9ddBu_SukSVWjFuVY6UdmemtsWTbNy3Srid3Rd2-IcTQo_mZmx5IWWOqlL_GjPO9-F4LE2a98srd8aCmZn3-zsm519s7OfFq4OMTblEqs__Fc3_wFrR32X</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Beslow, Lauren A</creator><creator>Dowling, Michael M</creator><creator>Hassanein, Sahar M A</creator><creator>Lynch, John K</creator><creator>Zafeiriou, Dimitrios</creator><creator>Sun, Lisa R</creator><creator>Kopyta, Ilona</creator><creator>Titomanlio, Luigi</creator><creator>Kolk, Anneli</creator><creator>Chan, Anthony</creator><creator>Biller, Jose</creator><creator>Grabowski, Eric F</creator><creator>Abdalla, Abdalla A</creator><creator>Mackay, Mark T</creator><creator>deVeber, Gabrielle</creator><general>American Academy of Pediatrics</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Mortality After Pediatric Arterial Ischemic Stroke</title><author>Beslow, Lauren A ; Dowling, Michael M ; Hassanein, Sahar M A ; Lynch, John K ; Zafeiriou, Dimitrios ; Sun, Lisa R ; Kopyta, Ilona ; Titomanlio, Luigi ; Kolk, Anneli ; Chan, Anthony ; Biller, Jose ; Grabowski, Eric F ; Abdalla, Abdalla A ; Mackay, Mark T ; deVeber, Gabrielle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-84481aaab5b0ecc790607fca9619706515bc7f5a367ab2d79d73f978ce60bd2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Child health</topic><topic>Child mortality</topic><topic>Children</topic><topic>Coronary artery disease</topic><topic>Death</topic><topic>Ethnicity</topic><topic>Fatalities</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Heart diseases</topic><topic>Hospitalization</topic><topic>Ischemia</topic><topic>Medical records</topic><topic>Minority & ethnic groups</topic><topic>Mortality</topic><topic>Neonates</topic><topic>Patient outcomes</topic><topic>Pediatrics</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Seizures</topic><topic>Statistics</topic><topic>Stroke</topic><topic>Stroke (Disease)</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beslow, Lauren A</creatorcontrib><creatorcontrib>Dowling, Michael M</creatorcontrib><creatorcontrib>Hassanein, Sahar M A</creatorcontrib><creatorcontrib>Lynch, John K</creatorcontrib><creatorcontrib>Zafeiriou, Dimitrios</creatorcontrib><creatorcontrib>Sun, Lisa R</creatorcontrib><creatorcontrib>Kopyta, Ilona</creatorcontrib><creatorcontrib>Titomanlio, Luigi</creatorcontrib><creatorcontrib>Kolk, Anneli</creatorcontrib><creatorcontrib>Chan, Anthony</creatorcontrib><creatorcontrib>Biller, Jose</creatorcontrib><creatorcontrib>Grabowski, Eric F</creatorcontrib><creatorcontrib>Abdalla, Abdalla A</creatorcontrib><creatorcontrib>Mackay, Mark T</creatorcontrib><creatorcontrib>deVeber, Gabrielle</creatorcontrib><creatorcontrib>International Pediatric Stroke Study Investigators</creatorcontrib><creatorcontrib>on behalf of the International Pediatric Stroke Study Investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beslow, Lauren A</au><au>Dowling, Michael M</au><au>Hassanein, Sahar M A</au><au>Lynch, John K</au><au>Zafeiriou, Dimitrios</au><au>Sun, Lisa R</au><au>Kopyta, Ilona</au><au>Titomanlio, Luigi</au><au>Kolk, Anneli</au><au>Chan, Anthony</au><au>Biller, Jose</au><au>Grabowski, Eric F</au><au>Abdalla, Abdalla A</au><au>Mackay, Mark T</au><au>deVeber, Gabrielle</au><aucorp>International Pediatric Stroke Study Investigators</aucorp><aucorp>on behalf of the International Pediatric Stroke Study Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality After Pediatric Arterial Ischemic Stroke</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2018-05</date><risdate>2018</risdate><volume>141</volume><issue>5</issue><spage>1</spage><pages>1-</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>Cerebrovascular disease is among the top 10 causes of death in US children, but risk factors for mortality are poorly understood. Within an international registry, we identify predictors of in-hospital mortality after pediatric arterial ischemic stroke (AIS).
Neonates (0-28 days) and children (29 days-<19 years) with AIS were enrolled from January 2003 to July 2014 in a multinational stroke registry. Death during hospitalization and cause of death were ascertained from medical records. Logistic regression was used to analyze associations between risk factors and in-hospital mortality.
Fourteen of 915 neonates (1.5%) and 70 of 2273 children (3.1%) died during hospitalization. Of 48 cases with reported causes of death, 31 (64.6%) were stroke-related, with remaining deaths attributed to medical disease. In multivariable analysis, congenital heart disease (odds ratio [OR]: 3.88; 95% confidence interval [CI]: 1.23-12.29;
= .021), posterior plus anterior circulation stroke (OR: 5.36; 95% CI: 1.70-16.85;
= .004), and stroke presentation without seizures (OR: 3.95; 95% CI: 1.26-12.37;
= .019) were associated with in-hospital mortality for neonates. Hispanic ethnicity (OR: 3.12; 95% CI: 1.56-6.24;
= .001), congenital heart disease (OR: 3.14; 95% CI: 1.75-5.61;
< .001), and posterior plus anterior circulation stroke (OR: 2.71; 95% CI: 1.40-5.25;
= .003) were associated with in-hospital mortality for children.
In-hospital mortality occurred in 2.6% of pediatric AIS cases. Most deaths were attributable to stroke. Risk factors for in-hospital mortality included congenital heart disease and posterior plus anterior circulation stroke. Presentation without seizures and Hispanic ethnicity were also associated with mortality for neonates and children, respectively. Awareness and study of risk factors for mortality represent opportunities to increase survival.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>29695585</pmid><doi>10.1542/peds.2017-4146</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-4005 |
| ispartof | Pediatrics (Evanston), 2018-05, Vol.141 (5), p.1 |
| issn | 0031-4005 1098-4275 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2031416413 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Analysis Child health Child mortality Children Coronary artery disease Death Ethnicity Fatalities Health aspects Health risks Heart diseases Hospitalization Ischemia Medical records Minority & ethnic groups Mortality Neonates Patient outcomes Pediatrics Regression analysis Risk factors Seizures Statistics Stroke Stroke (Disease) United States |
| title | Mortality After Pediatric Arterial Ischemic Stroke |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T16%3A37%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mortality%20After%20Pediatric%20Arterial%20Ischemic%20Stroke&rft.jtitle=Pediatrics%20(Evanston)&rft.au=Beslow,%20Lauren%20A&rft.aucorp=International%20Pediatric%20Stroke%20Study%20Investigators&rft.date=2018-05&rft.volume=141&rft.issue=5&rft.spage=1&rft.pages=1-&rft.issn=0031-4005&rft.eissn=1098-4275&rft_id=info:doi/10.1542/peds.2017-4146&rft_dat=%3Cgale_proqu%3EA538959003%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2089733979&rft_id=info:pmid/29695585&rft_galeid=A538959003&rfr_iscdi=true |