ZD7288 and mibefradil inhibit the myogenic heartbeat in Daphnia magna indicating its dependency on HCN and T-type calcium ion channels

Daphnia magna heartbeat is myogenic—originating within the animal's heart. However, the mechanism for this myogenic automaticity is unknown. The mechanism underlying the automaticity of vertebrate myogenic hearts involves cells (pacemaker cells), which have a distinct set of ion channels that i...

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Veröffentlicht in:	Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2018-08, Vol.222, p.36-42
Hauptverfasser:	Pirtle, Thomas J., Carr, Troy L., Khurana, Tanisha, Meeker, Grace
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - pharmacology Calcium Channels, T-Type - drug effects Cardiotonic Agents - administration & dosage Cardiotonic Agents - pharmacology Cyclic Nucleotide-Gated Cation Channels - drug effects Daphnia - physiology Daphnia magna Dose-Response Relationship, Drug HCN channel Heart Heart Rate - drug effects Mibefradil Mibefradil - administration & dosage Mibefradil - pharmacology Myogenic Pyrimidines - administration & dosage Pyrimidines - pharmacology T-type Ca2+ channel ZD7288
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