Angiotensin receptor blocker, losartan ameliorates neuroinflammation and behavioral consequences of lipopolysaccharide injection

Neuroinflammation has a critical role in brain diseases. Angiotensin II (Ang II) is an important player in inflammation via stimulating of Ang II type 1 receptor (AT1R). In this study, the effects of losartan, an Ang II receptor blocker, on the brain inflammation, oxidative stress and behavioral con...

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Veröffentlicht in:	Life sciences (1973) 2018-06, Vol.203, p.161-170
Hauptverfasser:	Salmani, Hossein, Hosseini, Mahmoud, Beheshti, Farimah, Baghcheghi, Yousef, Sadeghnia, Hamid Reza, Soukhtanloo, Mohammad, Shafei, Mohammad Naser, Khazaei, Majid
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Brain Brain diseases Catalase Chronic inflammation Depression Fear memory Hedonic response Inflammation Injection Interleukin 6 Lipopolysaccharides Malondialdehyde Memory Mental depression Metabolites Neuroinflammation Nitric oxide Oxidative stress Performance enhancement Pretreatment Rats Sucrose Sugar Superoxide dismutase Swimming
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