Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006–2015
ABSTRACT Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import–associated cases in Hokkaido district, Japan, during 2006–2015. In the present study, their antigenic features were evaluated by determining the complete nucleotide sequen...
Gespeichert in:
| Veröffentlicht in: | Microbiology and immunology 2018-06, Vol.62 (6), p.411-417 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 417 |
|---|---|
| container_issue | 6 |
| container_start_page | 411 |
| container_title | Microbiology and immunology |
| container_volume | 62 |
| creator | Miyoshi, Masahiro Komagome, Rika Yamaguchi, Hiroki Ishida, Setsuko Nagano, Hideki Okano, Motohiko |
| description | ABSTRACT
Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import–associated cases in Hokkaido district, Japan, during 2006–2015. In the present study, their antigenic features were evaluated by determining the complete nucleotide sequences of their hemagglutinin proteins, which are a major target for neutralizing antibodies, and their amino acid sequences deduced. It was found that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further infections thus far, these antigenic changes should continue to be monitored to maintain their elimination status. |
| doi_str_mv | 10.1111/1348-0421.12594 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2031028025</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2057173981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4634-a6607cade07e397d6215f7f209258bb9877bb3ff571d7059ccc973e226efaefc3</originalsourceid><addsrcrecordid>eNqFkb1OHTEQhS1EBDdAnS5aiSYFC2N7vbbLCBEgAqWB2vJ6x2DYnxt7F0SqvEPekCfBl0so0mSakWa-OTM6Q8gnCoc0xxHllSqhYvSQMqGrDbJ4r2ySBXAlSlEDbJOPKd0BMMlUtUW2ma6V1FQtSH-KA07BFe7WRusmjOGXncI4FKMvbrG3NzfdPIUhDMUyjhOG10aPNnWYiocQ55Rzrp6N9_c2tGPRhjTF4KaD4rtd2uGgYAD18-8_DKjYJR-87RLuveUdcv3t5Or4rLz4cXp-_PWidFXNq9LWNUhnWwSJXMu2ZlR46RloJlTTaCVl03DvhaStBKGdc1pyZKxGb9E7vkO-rHXzzT9nTJPpQ3LYdXbAcU6GAafAFDCR0f1_0LtxjkO-LlN5geRa0UwdrSkXx5QierOMobfxyVAwq0-Yle9m5bt5_USe-PymOzc9tu_8X-szINbAY-jw6X965vL8ci38Aplgkm4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2057173981</pqid></control><display><type>article</type><title>Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006–2015</title><source>Wiley Free Content</source><source>Freely Accessible Japanese Titles</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Miyoshi, Masahiro ; Komagome, Rika ; Yamaguchi, Hiroki ; Ishida, Setsuko ; Nagano, Hideki ; Okano, Motohiko</creator><creatorcontrib>Miyoshi, Masahiro ; Komagome, Rika ; Yamaguchi, Hiroki ; Ishida, Setsuko ; Nagano, Hideki ; Okano, Motohiko</creatorcontrib><description>ABSTRACT
Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import–associated cases in Hokkaido district, Japan, during 2006–2015. In the present study, their antigenic features were evaluated by determining the complete nucleotide sequences of their hemagglutinin proteins, which are a major target for neutralizing antibodies, and their amino acid sequences deduced. It was found that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further infections thus far, these antigenic changes should continue to be monitored to maintain their elimination status.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/1348-0421.12594</identifier><identifier>PMID: 29687918</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Amino acid sequence ; Epidemics ; Genotypes ; hemagglutinin ; Hemagglutinins ; Hokkaido ; Measles ; measles virus ; Proteins ; Strains (organisms) ; Viruses</subject><ispartof>Microbiology and immunology, 2018-06, Vol.62 (6), p.411-417</ispartof><rights>2018 The Societies and John Wiley & Sons Australia, Ltd</rights><rights>2018 The Societies and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4634-a6607cade07e397d6215f7f209258bb9877bb3ff571d7059ccc973e226efaefc3</citedby><cites>FETCH-LOGICAL-c4634-a6607cade07e397d6215f7f209258bb9877bb3ff571d7059ccc973e226efaefc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1348-0421.12594$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1348-0421.12594$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29687918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyoshi, Masahiro</creatorcontrib><creatorcontrib>Komagome, Rika</creatorcontrib><creatorcontrib>Yamaguchi, Hiroki</creatorcontrib><creatorcontrib>Ishida, Setsuko</creatorcontrib><creatorcontrib>Nagano, Hideki</creatorcontrib><creatorcontrib>Okano, Motohiko</creatorcontrib><title>Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006–2015</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>ABSTRACT
Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import–associated cases in Hokkaido district, Japan, during 2006–2015. In the present study, their antigenic features were evaluated by determining the complete nucleotide sequences of their hemagglutinin proteins, which are a major target for neutralizing antibodies, and their amino acid sequences deduced. It was found that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further infections thus far, these antigenic changes should continue to be monitored to maintain their elimination status.</description><subject>Amino acid sequence</subject><subject>Epidemics</subject><subject>Genotypes</subject><subject>hemagglutinin</subject><subject>Hemagglutinins</subject><subject>Hokkaido</subject><subject>Measles</subject><subject>measles virus</subject><subject>Proteins</subject><subject>Strains (organisms)</subject><subject>Viruses</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkb1OHTEQhS1EBDdAnS5aiSYFC2N7vbbLCBEgAqWB2vJ6x2DYnxt7F0SqvEPekCfBl0so0mSakWa-OTM6Q8gnCoc0xxHllSqhYvSQMqGrDbJ4r2ySBXAlSlEDbJOPKd0BMMlUtUW2ma6V1FQtSH-KA07BFe7WRusmjOGXncI4FKMvbrG3NzfdPIUhDMUyjhOG10aPNnWYiocQ55Rzrp6N9_c2tGPRhjTF4KaD4rtd2uGgYAD18-8_DKjYJR-87RLuveUdcv3t5Or4rLz4cXp-_PWidFXNq9LWNUhnWwSJXMu2ZlR46RloJlTTaCVl03DvhaStBKGdc1pyZKxGb9E7vkO-rHXzzT9nTJPpQ3LYdXbAcU6GAafAFDCR0f1_0LtxjkO-LlN5geRa0UwdrSkXx5QierOMobfxyVAwq0-Yle9m5bt5_USe-PymOzc9tu_8X-szINbAY-jw6X965vL8ci38Aplgkm4</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Miyoshi, Masahiro</creator><creator>Komagome, Rika</creator><creator>Yamaguchi, Hiroki</creator><creator>Ishida, Setsuko</creator><creator>Nagano, Hideki</creator><creator>Okano, Motohiko</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006–2015</title><author>Miyoshi, Masahiro ; Komagome, Rika ; Yamaguchi, Hiroki ; Ishida, Setsuko ; Nagano, Hideki ; Okano, Motohiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4634-a6607cade07e397d6215f7f209258bb9877bb3ff571d7059ccc973e226efaefc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amino acid sequence</topic><topic>Epidemics</topic><topic>Genotypes</topic><topic>hemagglutinin</topic><topic>Hemagglutinins</topic><topic>Hokkaido</topic><topic>Measles</topic><topic>measles virus</topic><topic>Proteins</topic><topic>Strains (organisms)</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyoshi, Masahiro</creatorcontrib><creatorcontrib>Komagome, Rika</creatorcontrib><creatorcontrib>Yamaguchi, Hiroki</creatorcontrib><creatorcontrib>Ishida, Setsuko</creatorcontrib><creatorcontrib>Nagano, Hideki</creatorcontrib><creatorcontrib>Okano, Motohiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyoshi, Masahiro</au><au>Komagome, Rika</au><au>Yamaguchi, Hiroki</au><au>Ishida, Setsuko</au><au>Nagano, Hideki</au><au>Okano, Motohiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006–2015</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiol Immunol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>62</volume><issue>6</issue><spage>411</spage><epage>417</epage><pages>411-417</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><abstract>ABSTRACT
Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import–associated cases in Hokkaido district, Japan, during 2006–2015. In the present study, their antigenic features were evaluated by determining the complete nucleotide sequences of their hemagglutinin proteins, which are a major target for neutralizing antibodies, and their amino acid sequences deduced. It was found that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further infections thus far, these antigenic changes should continue to be monitored to maintain their elimination status.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29687918</pmid><doi>10.1111/1348-0421.12594</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-5600 |
| ispartof | Microbiology and immunology, 2018-06, Vol.62 (6), p.411-417 |
| issn | 0385-5600 1348-0421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2031028025 |
| source | Wiley Free Content; Freely Accessible Japanese Titles; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Amino acid sequence Epidemics Genotypes hemagglutinin Hemagglutinins Hokkaido Measles measles virus Proteins Strains (organisms) Viruses |
| title | Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006–2015 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T12%3A21%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20characterization%20of%20hemagglutinin%20protein%20of%20measles%20viruses%20in%20Hokkaido%20district,%20Japan,%202006%E2%80%932015&rft.jtitle=Microbiology%20and%20immunology&rft.au=Miyoshi,%20Masahiro&rft.date=2018-06&rft.volume=62&rft.issue=6&rft.spage=411&rft.epage=417&rft.pages=411-417&rft.issn=0385-5600&rft.eissn=1348-0421&rft_id=info:doi/10.1111/1348-0421.12594&rft_dat=%3Cproquest_cross%3E2057173981%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2057173981&rft_id=info:pmid/29687918&rfr_iscdi=true |