Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination

Spinocerebellar ataxia type 3 is a neurodegenerative disease caused by expansion of a polyglutamine domain in the protein ataxin-3 (ATXN3). Physiological functions of ATXN3 presumably include ubiquitin protease and transcriptional corepressor activity. To gain insight into the function of ATXN3 and...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-10, Vol.362 (3), p.734-739
Hauptverfasser:	Schmitt, Ina, Linden, Marion, Khazneh, Hassan, Evert, Bernd O., Breuer, Peter, Klockgether, Thomas, Wuellner, Ullrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety Ataxin-3 Behavior, Animal Brain - metabolism Deubiquitinating enzyme DUB Female Knockout Male Mice Mice, Inbred C57BL Mice, Knockout Models, Biological Neurodegeneration Neurodegenerative Diseases - metabolism Nuclear Proteins - genetics Nuclear Proteins - physiology Peptides - metabolism Polyglutamine SCA3 Testis - metabolism Tissue Distribution Transcription Factors - genetics Transcription Factors - physiology Ubiquitin - metabolism
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