The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF

Therapies targeting certain CFTR mutants have been approved, yet variations in clinical response highlight the need for in-vitro and genetic tools that predict patient-specific clinical outcomes. Toward this goal, the CF Canada-Sick Kids Program in Individual CF Therapy (CFIT) is generating a “first...

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Veröffentlicht in:	Journal of cystic fibrosis 2019-01, Vol.18 (1), p.35-43
Hauptverfasser:	Eckford, Paul D.W., McCormack, Jacqueline, Munsie, Lise, He, Gengming, Stanojevic, Sanja, Pereira, Sergio L., Ho, Karen, Avolio, Julie, Bartlett, Claire, Yang, Jin Ye, Wong, Amy P., Wellhauser, Leigh, Huan, Ling Jun, Jiang, Jia Xin, Ouyang, Hong, Du, Kai, Klingel, Michelle, Kyriakopoulou, Lianna, Gonska, Tanja, Moraes, Theo J., Strug, Lisa J., Rossant, Janet, Ratjen, Felix, Bear, Christine E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminophenols - therapeutic use Aminopyridines - therapeutic use Benzodioxoles - therapeutic use Canada - epidemiology Child Clinical outcome data Cultures Cystic Fibrosis - epidemiology Cystic Fibrosis - genetics Cystic Fibrosis - therapy Cystic Fibrosis Transmembrane Conductance Regulator - genetics Drug Combinations Drug responses Genetic Therapy - methods Humans Incidence Mutation, Missense Nasal Patient-specific primary tissues Pluripotent stem cells Precision medicine Precision Medicine - methods Program Development - methods Quinolones - therapeutic use Resource for discovery RNA - genetics RNAseq Whole genome sequencing
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