C-Phycocyanin inhibits hepatic gluconeogenesis and increases glycogen synthesis via activating Akt and AMPK in insulin resistance hepatocytes

C-Phycocyanin (C-PC), a kind of blue protein isolated from Spirulina platensis, can ameliorate hyperglycemia, but its effects on gluconeogenesis and glycogenesis are unknown. In the present study, we investigated the effects and underlying mechanisms of C-PC on gluconeogenesis and glycogenesis in in...

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Veröffentlicht in:	Food & function 2018-05, Vol.9 (5), p.2829-2839
Hauptverfasser:	Ren, Zhiheng, Xie, Zhifei, Cao, Danni, Gong, Mufeng, Yang, Lei, Zhou, Zhu, Ou, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Down-Regulation - drug effects Gluconeogenesis Gluconeogenesis - drug effects Glucose Glucose - biosynthesis Glucose-6-phosphatase Glycogen Glycogen - biosynthesis Glycogen synthase Hep G2 Cells Hepatocellular carcinoma Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Humans Hyperglycemia Insulin Insulin - metabolism Insulin Resistance Liver - drug effects Liver - metabolism LKB1 protein Phycocyanin Phycocyanin - pharmacology Plant Extracts - pharmacology Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal transduction SIRT1 protein Spirulina - chemistry
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