Droplet Behavior in Open Biphasic Microfluidics

Capillary open microsystems are attractive and increasingly used in biotechnology, biology, and diagnostics as they allow simple and reliable control of fluid flows. In contrast to closed microfluidic systems, however, two-phase capillary flows in open microfluidics have remained largely unexplored....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Langmuir 2018-05, Vol.34 (18), p.5358-5366
Hauptverfasser: Lee, Jing J, Berthier, Jean, Brakke, Kenneth A, Dostie, Ashley M, Theberge, Ashleigh B, Berthier, Erwin
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 5366
container_issue 18
container_start_page 5358
container_title Langmuir
container_volume 34
creator Lee, Jing J
Berthier, Jean
Brakke, Kenneth A
Dostie, Ashley M
Theberge, Ashleigh B
Berthier, Erwin
description Capillary open microsystems are attractive and increasingly used in biotechnology, biology, and diagnostics as they allow simple and reliable control of fluid flows. In contrast to closed microfluidic systems, however, two-phase capillary flows in open microfluidics have remained largely unexplored. In this work, we present the theoretical basis and experimental demonstration of a spontaneous capillary flow (SCF) of two-phase systems in open microchannels. Analytical results show that an immiscible plug placed in an open channel can never stop the SCF of a fluid in a uniform cross-section microchannel. Numerical investigations of the morphologies of immiscible plugs in a capillary flow reveal three different possible behaviors. Finally, the predicted behaviors of the plugs are demonstrated experimentally, revealing an effect of inertial forces on the plug behavior. A model for predicting plug behaviors in SCFs is proposed, enabling the design of open microfluidic droplet-based systems that are simple to fabricate and use. The open-channel approach to droplet-based microfluidics has the potential to enable applications in which each drop can be accessed at any time and any location with simple pipettes or other fluid dispensing systems.
doi_str_mv 10.1021/acs.langmuir.8b00380
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2030919305</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2030919305</sourcerecordid><originalsourceid>FETCH-LOGICAL-a385t-31676419081bec0d4803d86da571d804f54fbb3819db2ed4046516688a1987003</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwBwhlySbtOH7EXtKWl1TUDawtJ3aoq7ywGyT-HldtWbKazbkzcw9CtximGDI802WY1rr9bAbnp6IAIALO0BizDFImsvwcjSGnJM0pJyN0FcIWACSh8hKNMsllhnMyRrOl7_ra7pK53ehv1_nEtcm6t20yd_1GB1cmb670XVUPzrgyXKOLStfB3hznBH08Pb4vXtLV-vl18bBKNRFslxLMc06xBIELW4KhAogR3GiWYyOAVoxWRUEElqbIrKFAOcOcC6GxFHnsMkH3h729774GG3aqcaG0dWxsuyGoDAhILAmwiNIDGt8MwdtK9d412v8oDGqvSkVV6qRKHVXF2N3xwlA01vyFTm4iAAdgH992g29j4f93_gKKQ3Y2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2030919305</pqid></control><display><type>article</type><title>Droplet Behavior in Open Biphasic Microfluidics</title><source>American Chemical Society Publications</source><creator>Lee, Jing J ; Berthier, Jean ; Brakke, Kenneth A ; Dostie, Ashley M ; Theberge, Ashleigh B ; Berthier, Erwin</creator><creatorcontrib>Lee, Jing J ; Berthier, Jean ; Brakke, Kenneth A ; Dostie, Ashley M ; Theberge, Ashleigh B ; Berthier, Erwin</creatorcontrib><description>Capillary open microsystems are attractive and increasingly used in biotechnology, biology, and diagnostics as they allow simple and reliable control of fluid flows. In contrast to closed microfluidic systems, however, two-phase capillary flows in open microfluidics have remained largely unexplored. In this work, we present the theoretical basis and experimental demonstration of a spontaneous capillary flow (SCF) of two-phase systems in open microchannels. Analytical results show that an immiscible plug placed in an open channel can never stop the SCF of a fluid in a uniform cross-section microchannel. Numerical investigations of the morphologies of immiscible plugs in a capillary flow reveal three different possible behaviors. Finally, the predicted behaviors of the plugs are demonstrated experimentally, revealing an effect of inertial forces on the plug behavior. A model for predicting plug behaviors in SCFs is proposed, enabling the design of open microfluidic droplet-based systems that are simple to fabricate and use. The open-channel approach to droplet-based microfluidics has the potential to enable applications in which each drop can be accessed at any time and any location with simple pipettes or other fluid dispensing systems.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/acs.langmuir.8b00380</identifier><identifier>PMID: 29692173</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><ispartof>Langmuir, 2018-05, Vol.34 (18), p.5358-5366</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a385t-31676419081bec0d4803d86da571d804f54fbb3819db2ed4046516688a1987003</citedby><cites>FETCH-LOGICAL-a385t-31676419081bec0d4803d86da571d804f54fbb3819db2ed4046516688a1987003</cites><orcidid>0000-0002-4421-9034</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.langmuir.8b00380$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.langmuir.8b00380$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29692173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jing J</creatorcontrib><creatorcontrib>Berthier, Jean</creatorcontrib><creatorcontrib>Brakke, Kenneth A</creatorcontrib><creatorcontrib>Dostie, Ashley M</creatorcontrib><creatorcontrib>Theberge, Ashleigh B</creatorcontrib><creatorcontrib>Berthier, Erwin</creatorcontrib><title>Droplet Behavior in Open Biphasic Microfluidics</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>Capillary open microsystems are attractive and increasingly used in biotechnology, biology, and diagnostics as they allow simple and reliable control of fluid flows. In contrast to closed microfluidic systems, however, two-phase capillary flows in open microfluidics have remained largely unexplored. In this work, we present the theoretical basis and experimental demonstration of a spontaneous capillary flow (SCF) of two-phase systems in open microchannels. Analytical results show that an immiscible plug placed in an open channel can never stop the SCF of a fluid in a uniform cross-section microchannel. Numerical investigations of the morphologies of immiscible plugs in a capillary flow reveal three different possible behaviors. Finally, the predicted behaviors of the plugs are demonstrated experimentally, revealing an effect of inertial forces on the plug behavior. A model for predicting plug behaviors in SCFs is proposed, enabling the design of open microfluidic droplet-based systems that are simple to fabricate and use. The open-channel approach to droplet-based microfluidics has the potential to enable applications in which each drop can be accessed at any time and any location with simple pipettes or other fluid dispensing systems.</description><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwBwhlySbtOH7EXtKWl1TUDawtJ3aoq7ywGyT-HldtWbKazbkzcw9CtximGDI802WY1rr9bAbnp6IAIALO0BizDFImsvwcjSGnJM0pJyN0FcIWACSh8hKNMsllhnMyRrOl7_ra7pK53ehv1_nEtcm6t20yd_1GB1cmb670XVUPzrgyXKOLStfB3hznBH08Pb4vXtLV-vl18bBKNRFslxLMc06xBIELW4KhAogR3GiWYyOAVoxWRUEElqbIrKFAOcOcC6GxFHnsMkH3h729774GG3aqcaG0dWxsuyGoDAhILAmwiNIDGt8MwdtK9d412v8oDGqvSkVV6qRKHVXF2N3xwlA01vyFTm4iAAdgH992g29j4f93_gKKQ3Y2</recordid><startdate>20180508</startdate><enddate>20180508</enddate><creator>Lee, Jing J</creator><creator>Berthier, Jean</creator><creator>Brakke, Kenneth A</creator><creator>Dostie, Ashley M</creator><creator>Theberge, Ashleigh B</creator><creator>Berthier, Erwin</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4421-9034</orcidid></search><sort><creationdate>20180508</creationdate><title>Droplet Behavior in Open Biphasic Microfluidics</title><author>Lee, Jing J ; Berthier, Jean ; Brakke, Kenneth A ; Dostie, Ashley M ; Theberge, Ashleigh B ; Berthier, Erwin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a385t-31676419081bec0d4803d86da571d804f54fbb3819db2ed4046516688a1987003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jing J</creatorcontrib><creatorcontrib>Berthier, Jean</creatorcontrib><creatorcontrib>Brakke, Kenneth A</creatorcontrib><creatorcontrib>Dostie, Ashley M</creatorcontrib><creatorcontrib>Theberge, Ashleigh B</creatorcontrib><creatorcontrib>Berthier, Erwin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jing J</au><au>Berthier, Jean</au><au>Brakke, Kenneth A</au><au>Dostie, Ashley M</au><au>Theberge, Ashleigh B</au><au>Berthier, Erwin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Droplet Behavior in Open Biphasic Microfluidics</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2018-05-08</date><risdate>2018</risdate><volume>34</volume><issue>18</issue><spage>5358</spage><epage>5366</epage><pages>5358-5366</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><abstract>Capillary open microsystems are attractive and increasingly used in biotechnology, biology, and diagnostics as they allow simple and reliable control of fluid flows. In contrast to closed microfluidic systems, however, two-phase capillary flows in open microfluidics have remained largely unexplored. In this work, we present the theoretical basis and experimental demonstration of a spontaneous capillary flow (SCF) of two-phase systems in open microchannels. Analytical results show that an immiscible plug placed in an open channel can never stop the SCF of a fluid in a uniform cross-section microchannel. Numerical investigations of the morphologies of immiscible plugs in a capillary flow reveal three different possible behaviors. Finally, the predicted behaviors of the plugs are demonstrated experimentally, revealing an effect of inertial forces on the plug behavior. A model for predicting plug behaviors in SCFs is proposed, enabling the design of open microfluidic droplet-based systems that are simple to fabricate and use. The open-channel approach to droplet-based microfluidics has the potential to enable applications in which each drop can be accessed at any time and any location with simple pipettes or other fluid dispensing systems.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>29692173</pmid><doi>10.1021/acs.langmuir.8b00380</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4421-9034</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0743-7463
ispartof Langmuir, 2018-05, Vol.34 (18), p.5358-5366
issn 0743-7463
1520-5827
language eng
recordid cdi_proquest_miscellaneous_2030919305
source American Chemical Society Publications
title Droplet Behavior in Open Biphasic Microfluidics
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A12%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Droplet%20Behavior%20in%20Open%20Biphasic%20Microfluidics&rft.jtitle=Langmuir&rft.au=Lee,%20Jing%20J&rft.date=2018-05-08&rft.volume=34&rft.issue=18&rft.spage=5358&rft.epage=5366&rft.pages=5358-5366&rft.issn=0743-7463&rft.eissn=1520-5827&rft_id=info:doi/10.1021/acs.langmuir.8b00380&rft_dat=%3Cproquest_cross%3E2030919305%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2030919305&rft_id=info:pmid/29692173&rfr_iscdi=true