Polyamine-mediated post-transcriptional regulation of COX-2

Polyamines are involved in various cellular processes including embryonic development, cell growth and cell cycle regulation, apoptosis and carcinogenesis. Growing evidence suggests the importance of RNA processing and stability mediated by oncogenes and tumor suppressor genes in the development of...

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Veröffentlicht in:	Biochimie 2002-08, Vol.84 (8), p.815-819
Hauptverfasser:	Parker, Michele Taylor, Gerner, Eugene W
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics 3′-UTR Base Sequence Biogenic Polyamines - biosynthesis Biogenic Polyamines - pharmacology Blotting, Northern Caco-2 Cells COX-2 Cyclooxygenase 2 Eflornithine - pharmacology eIF-5A Enzyme Inhibitors - pharmacology Eukaryotic Translation Initiation Factor 5A Gene Expression Regulation, Enzymologic Humans Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - metabolism Membrane Proteins Models, Biological Peptide Initiation Factors - pharmacology Promoter Regions, Genetic - physiology Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Protein Processing, Post-Translational RNA, Messenger - biosynthesis RNA-Binding Proteins
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