Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice

We have recently demonstrated that naphthoquinone (NQ), one of extractable chemical compounds of diesel exhaust particles (DEP), enhances antigen-related airway inflammation with goblet cell hyperplasia in mice (Inoue et al. in Eur Respir J 209(2):259-267, 2007). Further, NQ has enhanced lung expres...

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Veröffentlicht in:	Archives of toxicology 2007-08, Vol.81 (8), p.575-581
Hauptverfasser:	INOUE, Ken-Ichiro, TAKANO, Hirohisa, ICHINOSE, Takamichi, TOMURA, Shigeo, YANAGISAWA, Rie, SAKURAI, Miho, SUMI, Daigo, CHO, Arthur K, HIYOSHI, Kyoko, KUMAGAI, Yoshito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - immunology Biological and medical sciences Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - pathology Bronchial Hyperreactivity - physiopathology Gene Expression Regulation - drug effects Interleukin-13 - metabolism Lung - drug effects Lung - metabolism Lung - pathology Lung - physiopathology Lungs Male Medical sciences Mice Mice, Inbred ICR Mucin 5AC Mucins - genetics Naphthoquinones - toxicity Ovalbumin - immunology Respiratory system RNA, Messenger - metabolism Toxicology Vehicle Emissions
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