Extracellular Nucleotides Block Bone Mineralization in Vitro: Evidence for Dual Inhibitory Mechanisms Involving Both P2Y sub(2) Receptors and Pyrophosphate

Extracellular nucleotides, signaling through P2 receptors, may act as local regulators of bone cell function. We investigated the effects of nucleotide agonists [ATP, ADP, uridine triphosphate (UTP), and uridine diphosphate] and pyrophosphate (PPi, a key physiological inhibitor of mineralization) on...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2007-09, Vol.148 (9), p.4208-4216
Hauptverfasser:	Orriss, Isabel R, Utting, Jennifer C, Brandao-Burch, Andrea, Colston, Kay, Grubb, Barbara R, Burnstock, Geoffrey, Arnett, Timothy R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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