Zinc Inhibits Doxorubicin-Activated Calcineurin Signal Transduction Pathway in H9c2 Embryonic Rat Cardiac Cells

Elevation of the zinc-binding protein metallothionein (MT) in the heart inhibits doxorubicin (DOX)-induced myocardial apoptosis and heart hypertrophy. Zinc release from MT in response to oxidative stress has been suggested as a mechanism of action of MT protection from DOX toxicity, and calcineurin...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2007-05, Vol.232 (5), p.682-689
Hauptverfasser:	Merten, Kevyn E., Jiang, Youchun, Kang, Y. James
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Calcineurin - metabolism Cell Line Cell Size - drug effects Cell Survival - drug effects Chelating Agents - pharmacology Chlorides - pharmacology Dose-Response Relationship, Drug Doxorubicin - pharmacology Ethylenediamines - pharmacology Luciferases - genetics Luciferases - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction - drug effects Transfection Zinc - metabolism Zinc - pharmacology Zinc Compounds - pharmacology
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