Vasoactive intestinal peptide induces CD4+,CD25+ T regulatory cells with therapeutic effect in collagen‐induced arthritis

Objective CD4+,CD25+ T regulatory cells (Treg) control the immune response to a variety of antigens, including self antigens, and may offer opportunities to intervene in the course of autoimmune diseases. Several models support the idea of the peripheral generation of CD4+,CD25+ Treg from CD4+,CD25−...

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Veröffentlicht in:	Arthritis and rheumatism 2006-03, Vol.54 (3), p.864-876
Hauptverfasser:	Gonzalez‐Rey, Elena, Fernandez‐Martin, Amelia, Chorny, Alejo, Delgado, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Collagen Disease Progression Diseases of the osteoarticular system Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Inflammatory joint diseases Male Medical sciences Mice Mice, Inbred DBA Receptors, Interleukin-2 - analysis T-Lymphocytes, Regulatory - immunology Vasoactive Intestinal Peptide - pharmacology Vasoactive Intestinal Peptide - therapeutic use
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