Structural and molecular study of the supraspinatus muscle of modern humans (Homo sapiens) and common chimpanzees (Pan troglodytes)
Objectives To analyze the muscle architecture and the expression pattern of the myosin heavy chain (MyHC) isoforms in the supraspinatus of Pan troglodytes and Homo sapiens in order to identify differences related to their different types of locomotion. Materials and methods We have analyzed nine sup...
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| Veröffentlicht in: | American journal of physical anthropology 2018-08, Vol.166 (4), p.934-940 |
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| container_title | American journal of physical anthropology |
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| creator | Potau, J. M. Casado, A. de Diego, M. Ciurana, N. Arias‐Martorell, J. Bello‐Hellegouarch, G. Barbosa, M. de Paz, F. J. Pastor, J. F. Pérez‐Pérez, A. |
| description | Objectives
To analyze the muscle architecture and the expression pattern of the myosin heavy chain (MyHC) isoforms in the supraspinatus of Pan troglodytes and Homo sapiens in order to identify differences related to their different types of locomotion.
Materials and methods
We have analyzed nine supraspinatus muscles of Pan troglodytes and ten of Homo sapiens. For each sample, we have recorded the muscle fascicle length (MFL), the pennation angle, and the physiological cross‐sectional area (PCSA). In the same samples, by real‐time quantitative polymerase chain reaction, we have assessed the percentages of expression of the MyHC‐I, MyHC‐IIa, and MyHC‐IIx isoforms.
Results
The mean MFL of the supraspinatus was longer (p = 0.001) and the PCSA was lower (p |
| doi_str_mv | 10.1002/ajpa.23490 |
| format | Article |
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To analyze the muscle architecture and the expression pattern of the myosin heavy chain (MyHC) isoforms in the supraspinatus of Pan troglodytes and Homo sapiens in order to identify differences related to their different types of locomotion.
Materials and methods
We have analyzed nine supraspinatus muscles of Pan troglodytes and ten of Homo sapiens. For each sample, we have recorded the muscle fascicle length (MFL), the pennation angle, and the physiological cross‐sectional area (PCSA). In the same samples, by real‐time quantitative polymerase chain reaction, we have assessed the percentages of expression of the MyHC‐I, MyHC‐IIa, and MyHC‐IIx isoforms.
Results
The mean MFL of the supraspinatus was longer (p = 0.001) and the PCSA was lower (p < 0.001) in Homo sapiens than in Pan troglodytes. Although the percentage of expression of MyHC‐IIa was lower in Homo sapiens than in Pan troglodytes (p = 0.035), the combination of MyHC‐IIa and MyHC‐IIx was expressed at a similar percentage in the two species.
Discussion
The longer MFL in the human supraspinatus is associated with a faster contractile velocity, which reflects the primary function of the upper limbs in Homo sapiens—the precise manipulation of objects—an adaptation to bipedal locomotion. In contrast, the larger PCSA in Pan troglodytes is related to the important role of the supraspinatus in stabilizing the glenohumeral joint during the support phase of knuckle‐walking. These functional differences of the supraspinatus in the two species are not reflected in differences in the expression of the MyHC isoforms.</description><identifier>ISSN: 0002-9483</identifier><identifier>EISSN: 1096-8644</identifier><identifier>EISSN: 2692-7691</identifier><identifier>DOI: 10.1002/ajpa.23490</identifier><identifier>PMID: 29681126</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Animals ; Anthropology, Physical ; Chemical analysis ; Female ; Hominids ; Humans ; Limbs ; Locomotion ; Male ; Manipulation ; Monkeys & apes ; muscle architecture ; Muscles ; myosin heavy chain isoforms ; Myosin Heavy Chains - analysis ; Myosin Heavy Chains - genetics ; Myosin Heavy Chains - metabolism ; Pan troglodytes - anatomy & histology ; Pan troglodytes - metabolism ; Primates ; Protein Isoforms ; Rotator Cuff - anatomy & histology ; Rotator Cuff - chemistry ; Rotator Cuff - metabolism ; Shoulder - anatomy & histology ; shoulder anatomy ; Upper limbs ; Walking</subject><ispartof>American journal of physical anthropology, 2018-08, Vol.166 (4), p.934-940</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3930-371412c0d673af29b7741c06050fda792ed9564337231f9abab8f0f467892e83</citedby><cites>FETCH-LOGICAL-c3930-371412c0d673af29b7741c06050fda792ed9564337231f9abab8f0f467892e83</cites><orcidid>0000-0003-3387-8760 ; 0000-0002-1442-1397</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajpa.23490$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajpa.23490$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29681126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Potau, J. M.</creatorcontrib><creatorcontrib>Casado, A.</creatorcontrib><creatorcontrib>de Diego, M.</creatorcontrib><creatorcontrib>Ciurana, N.</creatorcontrib><creatorcontrib>Arias‐Martorell, J.</creatorcontrib><creatorcontrib>Bello‐Hellegouarch, G.</creatorcontrib><creatorcontrib>Barbosa, M.</creatorcontrib><creatorcontrib>de Paz, F. J.</creatorcontrib><creatorcontrib>Pastor, J. F.</creatorcontrib><creatorcontrib>Pérez‐Pérez, A.</creatorcontrib><title>Structural and molecular study of the supraspinatus muscle of modern humans (Homo sapiens) and common chimpanzees (Pan troglodytes)</title><title>American journal of physical anthropology</title><addtitle>Am J Phys Anthropol</addtitle><description>Objectives
To analyze the muscle architecture and the expression pattern of the myosin heavy chain (MyHC) isoforms in the supraspinatus of Pan troglodytes and Homo sapiens in order to identify differences related to their different types of locomotion.
Materials and methods
We have analyzed nine supraspinatus muscles of Pan troglodytes and ten of Homo sapiens. For each sample, we have recorded the muscle fascicle length (MFL), the pennation angle, and the physiological cross‐sectional area (PCSA). In the same samples, by real‐time quantitative polymerase chain reaction, we have assessed the percentages of expression of the MyHC‐I, MyHC‐IIa, and MyHC‐IIx isoforms.
Results
The mean MFL of the supraspinatus was longer (p = 0.001) and the PCSA was lower (p < 0.001) in Homo sapiens than in Pan troglodytes. Although the percentage of expression of MyHC‐IIa was lower in Homo sapiens than in Pan troglodytes (p = 0.035), the combination of MyHC‐IIa and MyHC‐IIx was expressed at a similar percentage in the two species.
Discussion
The longer MFL in the human supraspinatus is associated with a faster contractile velocity, which reflects the primary function of the upper limbs in Homo sapiens—the precise manipulation of objects—an adaptation to bipedal locomotion. In contrast, the larger PCSA in Pan troglodytes is related to the important role of the supraspinatus in stabilizing the glenohumeral joint during the support phase of knuckle‐walking. These functional differences of the supraspinatus in the two species are not reflected in differences in the expression of the MyHC isoforms.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Anthropology, Physical</subject><subject>Chemical analysis</subject><subject>Female</subject><subject>Hominids</subject><subject>Humans</subject><subject>Limbs</subject><subject>Locomotion</subject><subject>Male</subject><subject>Manipulation</subject><subject>Monkeys & apes</subject><subject>muscle architecture</subject><subject>Muscles</subject><subject>myosin heavy chain isoforms</subject><subject>Myosin Heavy Chains - analysis</subject><subject>Myosin Heavy Chains - genetics</subject><subject>Myosin Heavy Chains - metabolism</subject><subject>Pan troglodytes - anatomy & histology</subject><subject>Pan troglodytes - metabolism</subject><subject>Primates</subject><subject>Protein Isoforms</subject><subject>Rotator Cuff - anatomy & histology</subject><subject>Rotator Cuff - chemistry</subject><subject>Rotator Cuff - metabolism</subject><subject>Shoulder - anatomy & histology</subject><subject>shoulder anatomy</subject><subject>Upper limbs</subject><subject>Walking</subject><issn>0002-9483</issn><issn>1096-8644</issn><issn>2692-7691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoModlu98QdIwJtWmJqvnSSXS7GtpWDB3g9nMxl3lnyMyYSy3vrHm-1WL7woBA7hfXg4yYvQB0rOKSHsC2wnOGdcaPIKLSjRbaNaIV6jBalpo4XiR-g45229tvW8RUdMt4pS1i7Qnx9zKmYuCRyG0GMfnTXFQcJ5Lv0OxwHPG4tzmRLkaQwwl4x9ycbZfeZjb1PAm-IhZHx6HX3EGabRhnz25DPR-xiw2Yx-gvDb2krdQcBzij9d7HezzWfv0JsBXLbvn-cJur_8en9x3dx-v_p2sbptDNecNFxSQZkhfSs5DEyvpRTU1CctydCD1Mz2etkKziXjdNCwhrUayCBaqWqm-Ak6PWinFH8Vm-fOj9lY5yDYWHLHSP0WrpSQFf30H7qNJYW6XKWUVFKL5Z76fKBMijknO3RTGj2kXUdJt2-m2zfTPTVT4Y_PyrL2tv-H_q2iAvQAPIzO7l5Qdaubu9VB-gi94ZkX</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Potau, J. M.</creator><creator>Casado, A.</creator><creator>de Diego, M.</creator><creator>Ciurana, N.</creator><creator>Arias‐Martorell, J.</creator><creator>Bello‐Hellegouarch, G.</creator><creator>Barbosa, M.</creator><creator>de Paz, F. J.</creator><creator>Pastor, J. F.</creator><creator>Pérez‐Pérez, A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3387-8760</orcidid><orcidid>https://orcid.org/0000-0002-1442-1397</orcidid></search><sort><creationdate>201808</creationdate><title>Structural and molecular study of the supraspinatus muscle of modern humans (Homo sapiens) and common chimpanzees (Pan troglodytes)</title><author>Potau, J. M. ; Casado, A. ; de Diego, M. ; Ciurana, N. ; Arias‐Martorell, J. ; Bello‐Hellegouarch, G. ; Barbosa, M. ; de Paz, F. J. ; Pastor, J. F. ; Pérez‐Pérez, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3930-371412c0d673af29b7741c06050fda792ed9564337231f9abab8f0f467892e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Anthropology, Physical</topic><topic>Chemical analysis</topic><topic>Female</topic><topic>Hominids</topic><topic>Humans</topic><topic>Limbs</topic><topic>Locomotion</topic><topic>Male</topic><topic>Manipulation</topic><topic>Monkeys & apes</topic><topic>muscle architecture</topic><topic>Muscles</topic><topic>myosin heavy chain isoforms</topic><topic>Myosin Heavy Chains - analysis</topic><topic>Myosin Heavy Chains - genetics</topic><topic>Myosin Heavy Chains - metabolism</topic><topic>Pan troglodytes - anatomy & histology</topic><topic>Pan troglodytes - metabolism</topic><topic>Primates</topic><topic>Protein Isoforms</topic><topic>Rotator Cuff - anatomy & histology</topic><topic>Rotator Cuff - chemistry</topic><topic>Rotator Cuff - metabolism</topic><topic>Shoulder - anatomy & histology</topic><topic>shoulder anatomy</topic><topic>Upper limbs</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Potau, J. M.</creatorcontrib><creatorcontrib>Casado, A.</creatorcontrib><creatorcontrib>de Diego, M.</creatorcontrib><creatorcontrib>Ciurana, N.</creatorcontrib><creatorcontrib>Arias‐Martorell, J.</creatorcontrib><creatorcontrib>Bello‐Hellegouarch, G.</creatorcontrib><creatorcontrib>Barbosa, M.</creatorcontrib><creatorcontrib>de Paz, F. J.</creatorcontrib><creatorcontrib>Pastor, J. F.</creatorcontrib><creatorcontrib>Pérez‐Pérez, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physical anthropology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Potau, J. M.</au><au>Casado, A.</au><au>de Diego, M.</au><au>Ciurana, N.</au><au>Arias‐Martorell, J.</au><au>Bello‐Hellegouarch, G.</au><au>Barbosa, M.</au><au>de Paz, F. J.</au><au>Pastor, J. F.</au><au>Pérez‐Pérez, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural and molecular study of the supraspinatus muscle of modern humans (Homo sapiens) and common chimpanzees (Pan troglodytes)</atitle><jtitle>American journal of physical anthropology</jtitle><addtitle>Am J Phys Anthropol</addtitle><date>2018-08</date><risdate>2018</risdate><volume>166</volume><issue>4</issue><spage>934</spage><epage>940</epage><pages>934-940</pages><issn>0002-9483</issn><eissn>1096-8644</eissn><eissn>2692-7691</eissn><abstract>Objectives
To analyze the muscle architecture and the expression pattern of the myosin heavy chain (MyHC) isoforms in the supraspinatus of Pan troglodytes and Homo sapiens in order to identify differences related to their different types of locomotion.
Materials and methods
We have analyzed nine supraspinatus muscles of Pan troglodytes and ten of Homo sapiens. For each sample, we have recorded the muscle fascicle length (MFL), the pennation angle, and the physiological cross‐sectional area (PCSA). In the same samples, by real‐time quantitative polymerase chain reaction, we have assessed the percentages of expression of the MyHC‐I, MyHC‐IIa, and MyHC‐IIx isoforms.
Results
The mean MFL of the supraspinatus was longer (p = 0.001) and the PCSA was lower (p < 0.001) in Homo sapiens than in Pan troglodytes. Although the percentage of expression of MyHC‐IIa was lower in Homo sapiens than in Pan troglodytes (p = 0.035), the combination of MyHC‐IIa and MyHC‐IIx was expressed at a similar percentage in the two species.
Discussion
The longer MFL in the human supraspinatus is associated with a faster contractile velocity, which reflects the primary function of the upper limbs in Homo sapiens—the precise manipulation of objects—an adaptation to bipedal locomotion. In contrast, the larger PCSA in Pan troglodytes is related to the important role of the supraspinatus in stabilizing the glenohumeral joint during the support phase of knuckle‐walking. These functional differences of the supraspinatus in the two species are not reflected in differences in the expression of the MyHC isoforms.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29681126</pmid><doi>10.1002/ajpa.23490</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3387-8760</orcidid><orcidid>https://orcid.org/0000-0002-1442-1397</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of physical anthropology, 2018-08, Vol.166 (4), p.934-940 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Aged Aged, 80 and over Animals Anthropology, Physical Chemical analysis Female Hominids Humans Limbs Locomotion Male Manipulation Monkeys & apes muscle architecture Muscles myosin heavy chain isoforms Myosin Heavy Chains - analysis Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Pan troglodytes - anatomy & histology Pan troglodytes - metabolism Primates Protein Isoforms Rotator Cuff - anatomy & histology Rotator Cuff - chemistry Rotator Cuff - metabolism Shoulder - anatomy & histology shoulder anatomy Upper limbs Walking |
| title | Structural and molecular study of the supraspinatus muscle of modern humans (Homo sapiens) and common chimpanzees (Pan troglodytes) |
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