Cyclization of PLP139-151 peptide reduces its encephalitogenic potential in experimental autoimmune encephalomyelitis

[Display omitted] We report the novel synthesis of cyclic PLP139-151 (cPLP) and its application in SJL/J mice to study its encephalitogenic effects. Our results indicate that the cPLP analog is minimally encephalitogenic when administered to induce experimental autoimmune encephalomyelitis (low dise...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2018-05, Vol.26 (9), p.2221-2228
Hauptverfasser:	Lourbopoulos, Athanasios, Matsoukas, Minos-Timotheos, Katsara, Maria, Deraos, George, Giannakopoulou, Aggeliki, Lagoudaki, Roza, Grigoriadis, Nikolaos, Matsoukas, John, Apostolopoulos, Vasso
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclic peptide Cyclic PLP peptide Experimental autoimmune encephalomyelitis Multiple sclerosis Proteolipid
Online-Zugang:	Volltext
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