Clonorchis sinensis cyclophilin A immunization protected mice from CLP-induced sepsis

Cyclophilin A (CyPA), ubiquitously existing in cytoplasm of all eukaryotes, can be secreted in response to inflammatory stimuli. Extracellular CyPA plays a prominent role in the pathological processes of inflammatory diseases, acting as a proinflammatory mediator, exerting chemotactic effects, promo...

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Veröffentlicht in:	International immunopharmacology 2018-06, Vol.59, p.347-353
Hauptverfasser:	Jiang, Juan, Yin, Hongling, Sun, Yao, Huang, Huaiqiu, Hu, Xuchu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Antibodies Antibodies - pharmacology Antibody Apoptosis Aspartate Aminotransferases - blood Bacterial Load Cecum Cecum - surgery Clonorchis sinensis Cyclophilin A - immunology Cyclopholin A (CyPA) Cytokines - blood Cytokines - genetics Cytoplasm Endothelial cells Eukaryotes Gene expression Immunization Immunoglobulins Infiltration Inflammatory diseases Inflammatory response Interleukin 6 Kidney - pathology Kidneys Ligation Lipopolysaccharides Liver Liver - pathology Lung - pathology Lungs Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 Parasites Peripheral blood Peritoneum Proteins Reactive Oxygen Species - metabolism Sepsis Sepsis - blood Sepsis - microbiology Sepsis - pathology Sepsis - therapy Surgery Systemic inflammatory response syndrome Therapeutic applications Tumor necrosis factor-α
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