Physiological movement disorder-like features during typical motor development
To compare physiological age-relatedness between dyskinesia (dystonia/choreoathetosis), dystonia and ataxia rating scale scores in healthy children. Three movement disorders specialists quantified dyskinetic-like features in healthy children (n = 52; 4–16 years) using the Dyskinesia Impairment Scale...
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| Veröffentlicht in: | European journal of paediatric neurology 2018-07, Vol.22 (4), p.595-601 |
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| creator | Kuiper, M.J. Brandsma, R. Vrijenhoek, L. Tijssen, M.A.J. Burger, H. Dan, B. Sival, D.A. |
| description | To compare physiological age-relatedness between dyskinesia (dystonia/choreoathetosis), dystonia and ataxia rating scale scores in healthy children.
Three movement disorders specialists quantified dyskinetic-like features in healthy children (n = 52; 4–16 years) using the Dyskinesia Impairment Scale (DIS = DIS-choreoathetosis (DIS-C) + DIS-dystonia (DIS-D)). We compared the age-related regression coefficients of the DIS with data processed from previous studies on dystonia and ataxia rating scales (Burke-Fahn-Marsden Movement and Disability Scales (BFMMS and BFMDS) and Scale for Assessment and Rating of Ataxia (SARA), International Cooperative Ataxia Rating Scale (ICARS) and Brief Ataxia Rating Scale (BARS)).
Dyskinetic scores were obtained in 79% (DIS); 65% (DIS-D) and 17% (DIS-C) versus dystonic and ataxic scores in 98% (BFMMS) and 89% (SARA/ICARS/BARS) of the children. Age-related DIS and DIS-D scores (B = −0.90 and 0.77; p |
| doi_str_mv | 10.1016/j.ejpn.2018.03.010 |
| format | Article |
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Three movement disorders specialists quantified dyskinetic-like features in healthy children (n = 52; 4–16 years) using the Dyskinesia Impairment Scale (DIS = DIS-choreoathetosis (DIS-C) + DIS-dystonia (DIS-D)). We compared the age-related regression coefficients of the DIS with data processed from previous studies on dystonia and ataxia rating scales (Burke-Fahn-Marsden Movement and Disability Scales (BFMMS and BFMDS) and Scale for Assessment and Rating of Ataxia (SARA), International Cooperative Ataxia Rating Scale (ICARS) and Brief Ataxia Rating Scale (BARS)).
Dyskinetic scores were obtained in 79% (DIS); 65% (DIS-D) and 17% (DIS-C) versus dystonic and ataxic scores in 98% (BFMMS) and 89% (SARA/ICARS/BARS) of the children. Age-related DIS and DIS-D scores (B = −0.90 and 0.77; p < 0.001) were correlated with age-related BFMMS scores (B = −0.49; p < 0.001; r = 0.87; p < 0.001), whereas DIS-C scores were age-independent. Ataxic scores revealed stronger age-related regression coefficients than dyskinetic and dystonic scores (4–8 years; p < 0.05).
In healthy children, comparison between physiological dyskinesia, dystonia and ataxia rating scale scores revealed: 1. inverse age-relatedness for dystonic and ataxic scores, but not for choreoathetotic scores, 2. interrelated dystonic DIS-D and BFMMS scores, 3. the strongest age-related expression by ataxic scores. In healthy children, these physiological movement disorder-like features are interpreted as an expression of the developing underlying motor centres.
In healthy children (4–16 years of age):•The Dyskinesia Impairment Scale (DIS) total and dystonia (DIS-D) (sub)scales are age-related.•DIS-D and BFMMS reveal similar age-related dystonia score profiles.•Choreoathetosis subscale scores are sparse and age-independent.•The youngest age subgroup (4–8 years) reveals stronger age-relatedness of ataxia than of dystonia rating scale scores.•The unique dystonic, ataxic and choreoathetotic score profiles are attributed to the underlying development of the associated motor centres.</description><identifier>ISSN: 1090-3798</identifier><identifier>EISSN: 1532-2130</identifier><identifier>DOI: 10.1016/j.ejpn.2018.03.010</identifier><identifier>PMID: 29680266</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Age ; Age Factors ; Ataxia ; Child ; Child Development - physiology ; Child, Preschool ; Children ; Dyskinesia ; Dyskinesias ; Dystonia ; Female ; Humans ; Male ; Motor Activity - physiology ; Movement disorder-like features ; Rating scales ; Severity of Illness Index</subject><ispartof>European journal of paediatric neurology, 2018-07, Vol.22 (4), p.595-601</ispartof><rights>2018 European Paediatric Neurology Society</rights><rights>Copyright © 2018 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-86a435fbe86bc14b4005b6f65bca4d71e5ca3641c5098068213bb4572cd44f9d3</citedby><cites>FETCH-LOGICAL-c356t-86a435fbe86bc14b4005b6f65bca4d71e5ca3641c5098068213bb4572cd44f9d3</cites><orcidid>0000-0002-2051-9876</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejpn.2018.03.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29680266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuiper, M.J.</creatorcontrib><creatorcontrib>Brandsma, R.</creatorcontrib><creatorcontrib>Vrijenhoek, L.</creatorcontrib><creatorcontrib>Tijssen, M.A.J.</creatorcontrib><creatorcontrib>Burger, H.</creatorcontrib><creatorcontrib>Dan, B.</creatorcontrib><creatorcontrib>Sival, D.A.</creatorcontrib><title>Physiological movement disorder-like features during typical motor development</title><title>European journal of paediatric neurology</title><addtitle>Eur J Paediatr Neurol</addtitle><description>To compare physiological age-relatedness between dyskinesia (dystonia/choreoathetosis), dystonia and ataxia rating scale scores in healthy children.
Three movement disorders specialists quantified dyskinetic-like features in healthy children (n = 52; 4–16 years) using the Dyskinesia Impairment Scale (DIS = DIS-choreoathetosis (DIS-C) + DIS-dystonia (DIS-D)). We compared the age-related regression coefficients of the DIS with data processed from previous studies on dystonia and ataxia rating scales (Burke-Fahn-Marsden Movement and Disability Scales (BFMMS and BFMDS) and Scale for Assessment and Rating of Ataxia (SARA), International Cooperative Ataxia Rating Scale (ICARS) and Brief Ataxia Rating Scale (BARS)).
Dyskinetic scores were obtained in 79% (DIS); 65% (DIS-D) and 17% (DIS-C) versus dystonic and ataxic scores in 98% (BFMMS) and 89% (SARA/ICARS/BARS) of the children. Age-related DIS and DIS-D scores (B = −0.90 and 0.77; p < 0.001) were correlated with age-related BFMMS scores (B = −0.49; p < 0.001; r = 0.87; p < 0.001), whereas DIS-C scores were age-independent. Ataxic scores revealed stronger age-related regression coefficients than dyskinetic and dystonic scores (4–8 years; p < 0.05).
In healthy children, comparison between physiological dyskinesia, dystonia and ataxia rating scale scores revealed: 1. inverse age-relatedness for dystonic and ataxic scores, but not for choreoathetotic scores, 2. interrelated dystonic DIS-D and BFMMS scores, 3. the strongest age-related expression by ataxic scores. In healthy children, these physiological movement disorder-like features are interpreted as an expression of the developing underlying motor centres.
In healthy children (4–16 years of age):•The Dyskinesia Impairment Scale (DIS) total and dystonia (DIS-D) (sub)scales are age-related.•DIS-D and BFMMS reveal similar age-related dystonia score profiles.•Choreoathetosis subscale scores are sparse and age-independent.•The youngest age subgroup (4–8 years) reveals stronger age-relatedness of ataxia than of dystonia rating scale scores.•The unique dystonic, ataxic and choreoathetotic score profiles are attributed to the underlying development of the associated motor centres.</description><subject>Adolescent</subject><subject>Age</subject><subject>Age Factors</subject><subject>Ataxia</subject><subject>Child</subject><subject>Child Development - physiology</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Dyskinesia</subject><subject>Dyskinesias</subject><subject>Dystonia</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Movement disorder-like features</subject><subject>Rating scales</subject><subject>Severity of Illness Index</subject><issn>1090-3798</issn><issn>1532-2130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EoqXwBxhQRpaE60fcRGJBFS8JAQPMVmLfFJckDnZSqf-elBZGpnuH7xzpfIScU0goUHm1SnDVtQkDmiXAE6BwQKY05SxmlMPh-EMOMZ_n2YSchLACgFwweUwmLJcZMCmn5Pn1YxOsq93S6qKOGrfGBts-MjY4b9DHtf3EqMKiHzyGyAzetsuo33R7vHc-MrjG2nXb3Ck5qoo64Nn-zsj73e3b4iF-erl_XNw8xZqnso8zWQieViVmstRUlAIgLWUl01IXwswpprrgUlCdQp6BzMY9ZSnSOdNGiCo3fEYud72dd18Dhl41Nmis66JFNwTFYJzIaUZhRNkO1d6F4LFSnbdN4TeKgtp6VCu19ai2HhVwBT-hi33_UDZo_iK_4kbgegfguHJt0augLbYajfWoe2Wc_a__G8O9hPA</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Kuiper, M.J.</creator><creator>Brandsma, R.</creator><creator>Vrijenhoek, L.</creator><creator>Tijssen, M.A.J.</creator><creator>Burger, H.</creator><creator>Dan, B.</creator><creator>Sival, D.A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2051-9876</orcidid></search><sort><creationdate>201807</creationdate><title>Physiological movement disorder-like features during typical motor development</title><author>Kuiper, M.J. ; Brandsma, R. ; Vrijenhoek, L. ; Tijssen, M.A.J. ; Burger, H. ; Dan, B. ; Sival, D.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-86a435fbe86bc14b4005b6f65bca4d71e5ca3641c5098068213bb4572cd44f9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Age Factors</topic><topic>Ataxia</topic><topic>Child</topic><topic>Child Development - physiology</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Dyskinesia</topic><topic>Dyskinesias</topic><topic>Dystonia</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Movement disorder-like features</topic><topic>Rating scales</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuiper, M.J.</creatorcontrib><creatorcontrib>Brandsma, R.</creatorcontrib><creatorcontrib>Vrijenhoek, L.</creatorcontrib><creatorcontrib>Tijssen, M.A.J.</creatorcontrib><creatorcontrib>Burger, H.</creatorcontrib><creatorcontrib>Dan, B.</creatorcontrib><creatorcontrib>Sival, D.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of paediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuiper, M.J.</au><au>Brandsma, R.</au><au>Vrijenhoek, L.</au><au>Tijssen, M.A.J.</au><au>Burger, H.</au><au>Dan, B.</au><au>Sival, D.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological movement disorder-like features during typical motor development</atitle><jtitle>European journal of paediatric neurology</jtitle><addtitle>Eur J Paediatr Neurol</addtitle><date>2018-07</date><risdate>2018</risdate><volume>22</volume><issue>4</issue><spage>595</spage><epage>601</epage><pages>595-601</pages><issn>1090-3798</issn><eissn>1532-2130</eissn><abstract>To compare physiological age-relatedness between dyskinesia (dystonia/choreoathetosis), dystonia and ataxia rating scale scores in healthy children.
Three movement disorders specialists quantified dyskinetic-like features in healthy children (n = 52; 4–16 years) using the Dyskinesia Impairment Scale (DIS = DIS-choreoathetosis (DIS-C) + DIS-dystonia (DIS-D)). We compared the age-related regression coefficients of the DIS with data processed from previous studies on dystonia and ataxia rating scales (Burke-Fahn-Marsden Movement and Disability Scales (BFMMS and BFMDS) and Scale for Assessment and Rating of Ataxia (SARA), International Cooperative Ataxia Rating Scale (ICARS) and Brief Ataxia Rating Scale (BARS)).
Dyskinetic scores were obtained in 79% (DIS); 65% (DIS-D) and 17% (DIS-C) versus dystonic and ataxic scores in 98% (BFMMS) and 89% (SARA/ICARS/BARS) of the children. Age-related DIS and DIS-D scores (B = −0.90 and 0.77; p < 0.001) were correlated with age-related BFMMS scores (B = −0.49; p < 0.001; r = 0.87; p < 0.001), whereas DIS-C scores were age-independent. Ataxic scores revealed stronger age-related regression coefficients than dyskinetic and dystonic scores (4–8 years; p < 0.05).
In healthy children, comparison between physiological dyskinesia, dystonia and ataxia rating scale scores revealed: 1. inverse age-relatedness for dystonic and ataxic scores, but not for choreoathetotic scores, 2. interrelated dystonic DIS-D and BFMMS scores, 3. the strongest age-related expression by ataxic scores. In healthy children, these physiological movement disorder-like features are interpreted as an expression of the developing underlying motor centres.
In healthy children (4–16 years of age):•The Dyskinesia Impairment Scale (DIS) total and dystonia (DIS-D) (sub)scales are age-related.•DIS-D and BFMMS reveal similar age-related dystonia score profiles.•Choreoathetosis subscale scores are sparse and age-independent.•The youngest age subgroup (4–8 years) reveals stronger age-relatedness of ataxia than of dystonia rating scale scores.•The unique dystonic, ataxic and choreoathetotic score profiles are attributed to the underlying development of the associated motor centres.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29680266</pmid><doi>10.1016/j.ejpn.2018.03.010</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2051-9876</orcidid></addata></record> |
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| subjects | Adolescent Age Age Factors Ataxia Child Child Development - physiology Child, Preschool Children Dyskinesia Dyskinesias Dystonia Female Humans Male Motor Activity - physiology Movement disorder-like features Rating scales Severity of Illness Index |
| title | Physiological movement disorder-like features during typical motor development |
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