Prenatal administration of indomethacin modulates Th2 cytokines in juvenile rats

Indomethacin (IND) suppresses the T-dependent antibody response (TDAR) in juvenile males when it is administered to pregnant rats during late gestation. In this study, the effect of IND on cytokine production in juvenile rats was examined to investigate the mechanism behind the suppression of antibo...

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Veröffentlicht in:	Toxicology letters 2009-02, Vol.185 (1), p.32-37
Hauptverfasser:	Kushima, Kiyoshi, Sakuma, Shozo, Furusawa, Shuichi, Fujiwara, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cytokines - biosynthesis Developmental immunotoxicity Dose-Response Relationship, Drug Female Fetus - drug effects Indomethacin Indomethacin - toxicity Interferon-gamma - biosynthesis Interleukin-2 - biosynthesis Interleukin-4 - biosynthesis Male Medical sciences Mitogenic stimulation Pregnancy Rat Rats Rats, Sprague-Dawley Th1/Th2 cytokines Th2 Cells - drug effects Th2 Cells - immunology Toxicology Tumor Necrosis Factor-alpha - biosynthesis
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