A quantitative high-throughput trapping assay as a measurement of potential for bioactivation

Idiosyncratic adverse drug reactions (ADRs) are one of the most common causes of pharmaceutical withdrawals and labeling changes. Most ADRs are caused by drugs that form reactive species that can bind covalently to macromolecules such as proteins. The current methodology for the measurement of coval...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Analytical biochemistry 2006-04, Vol.351 (2), p.266-272
Hauptverfasser:	Meneses-Lorente, Georgina, Sakatis, Melanie Zea, Schulz-Utermoehl, Timothy, Nardi, Claudio De, Watt, Alan P.
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 14C]potassium cyanide Autoanalysis Biotransformation Carbon Radioisotopes Covalent binding Drug Evaluation, Preclinical Drug-Related Side Effects and Adverse Reactions Humans Microsomes, Liver - metabolism Nicotine - metabolism Pharmaceutical Preparations - metabolism Potassium Cyanide Reactive metabolite Scintillation Counting - methods Sensitivity and Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!