DNA–polycation complexes Effect of polycation structure on physico-chemical and biological properties

The purpose of the study was to investigate the influence of cationic polymer structure on the formation of DNA–polycation complexes and their transfection activity. Primary, tertiary, and quaternary polyamines with molecular masses ranging from 8000 to 200,000 were investigated. DNA–cationic polyme...

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Veröffentlicht in:	Journal of biotechnology 2007-01, Vol.127 (4), p.679-693
Hauptverfasser:	Slita, A.V., Kasyanenko, N.A., Nazarova, O.V., Gavrilova, I.I., Eropkina, E.M., Sirotkin, A.K., Smirnova, T.D., Kiselev, O.I., Panarin, E.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Line, Tumor Cell Survival - drug effects Cells - drug effects Chemical Phenomena Chemistry, Physical DNA - chemistry DNA - metabolism Genes, Reporter Humans Macromolecular Substances - chemistry Molecular Structure Polyallylamine Polyamines - chemistry Polyamines - pharmacology Polyamines - toxicity Polycation–DNA complexes Polydimethylaminoethylmethacrylate Structure-Activity Relationship Transfection Transfection activity
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