Is acute pulmonary embolism more severe in the presence of obstructive sleep apnea? Results from an observational cohort study
Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly old...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2018-08, Vol.46 (2), p.253-259 |
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| container_title | Journal of thrombosis and thrombolysis |
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| creator | Konnerth, Dinah Schwarz, Florian Probst, Michael Seidler, Martin Wagner, Tanja Faul, Christian von Scheidt, Wolfgang Schwaiblmair, Martin Berghaus, Thomas M. |
| description | Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p |
| doi_str_mv | 10.1007/s11239-018-1665-7 |
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Results from an observational cohort study</title><source>Springer Nature - Complete Springer Journals</source><creator>Konnerth, Dinah ; Schwarz, Florian ; Probst, Michael ; Seidler, Martin ; Wagner, Tanja ; Faul, Christian ; von Scheidt, Wolfgang ; Schwaiblmair, Martin ; Berghaus, Thomas M.</creator><creatorcontrib>Konnerth, Dinah ; Schwarz, Florian ; Probst, Michael ; Seidler, Martin ; Wagner, Tanja ; Faul, Christian ; von Scheidt, Wolfgang ; Schwaiblmair, Martin ; Berghaus, Thomas M.</creatorcontrib><description>Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p < 0.001), had significantly impaired renal (p < 0.001) and left ventricular functions (p = 0.003), showed significantly elevated troponin I (p = 0.005) and D-dimer levels (p = 0.024), were hospitalised significantly longer (p < 0.001), and had significantly elevated PE severity scores (p = 0.015). Moderate or severe OSA was significantly (p = 0.006) more frequent among intermediate- and high-risk PE patients (81.0%) compared to the low-risk PE cohort (16.3%). Multiple logistic regression analysis revealed that PE patients in the AHI ≥ 15/h cohort were at significant risk for myocardial injury (p = 0.015). Based on clinical risk stratification models, patients with no relevant OSA syndrome tended to be at a lower risk for short-term mortality (p = 0.068). Acute PE might present more severely in OSA patients, possibly due to nocturnal hypoxemia or OSA-related hypercoagulability.</description><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1007/s11239-018-1665-7</identifier><identifier>PMID: 29675617</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Apnea ; Calcium-binding protein ; Cardiology ; Cohort analysis ; Embolism ; Embolisms ; Health risk assessment ; Heart ; Hematology ; Hypoxemia ; Lung diseases ; Medicine ; Medicine & Public Health ; Observational studies ; Pulmonary arteries ; Pulmonary embolisms ; Sleep ; Sleep apnea ; Sleep disorders ; Troponin ; Troponin I ; Ventricle</subject><ispartof>Journal of thrombosis and thrombolysis, 2018-08, Vol.46 (2), p.253-259</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Journal of Thrombosis and Thrombolysis is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f160b49ae90f3edbab5de909b86e624f753693bd776c3938dceb16c326f9cf9a3</citedby><cites>FETCH-LOGICAL-c372t-f160b49ae90f3edbab5de909b86e624f753693bd776c3938dceb16c326f9cf9a3</cites><orcidid>0000-0002-8551-6190</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11239-018-1665-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11239-018-1665-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29675617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Konnerth, Dinah</creatorcontrib><creatorcontrib>Schwarz, Florian</creatorcontrib><creatorcontrib>Probst, Michael</creatorcontrib><creatorcontrib>Seidler, Martin</creatorcontrib><creatorcontrib>Wagner, Tanja</creatorcontrib><creatorcontrib>Faul, Christian</creatorcontrib><creatorcontrib>von Scheidt, Wolfgang</creatorcontrib><creatorcontrib>Schwaiblmair, Martin</creatorcontrib><creatorcontrib>Berghaus, Thomas M.</creatorcontrib><title>Is acute pulmonary embolism more severe in the presence of obstructive sleep apnea? Results from an observational cohort study</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><addtitle>J Thromb Thrombolysis</addtitle><description>Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p < 0.001), had significantly impaired renal (p < 0.001) and left ventricular functions (p = 0.003), showed significantly elevated troponin I (p = 0.005) and D-dimer levels (p = 0.024), were hospitalised significantly longer (p < 0.001), and had significantly elevated PE severity scores (p = 0.015). Moderate or severe OSA was significantly (p = 0.006) more frequent among intermediate- and high-risk PE patients (81.0%) compared to the low-risk PE cohort (16.3%). Multiple logistic regression analysis revealed that PE patients in the AHI ≥ 15/h cohort were at significant risk for myocardial injury (p = 0.015). Based on clinical risk stratification models, patients with no relevant OSA syndrome tended to be at a lower risk for short-term mortality (p = 0.068). Acute PE might present more severely in OSA patients, possibly due to nocturnal hypoxemia or OSA-related hypercoagulability.</description><subject>Apnea</subject><subject>Calcium-binding protein</subject><subject>Cardiology</subject><subject>Cohort analysis</subject><subject>Embolism</subject><subject>Embolisms</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Hematology</subject><subject>Hypoxemia</subject><subject>Lung diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Observational studies</subject><subject>Pulmonary arteries</subject><subject>Pulmonary embolisms</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep disorders</subject><subject>Troponin</subject><subject>Troponin I</subject><subject>Ventricle</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU2LFDEQhoMo7rj6A7xIwIuX1nxMks5JZPFjYUEQBW8hna64vXR32lQysBd_uxlnVRA8VUE99VbIQ8hTzl5yxswr5FxI2zHed1xr1Zl7ZMeVkZ3Zi6_3yY5ZYTslmTojjxBvGGPWMvGQnAmrjdLc7MiPS6Q-1AJ0q_OSVp9vKSxDmidc6JIyUIQDtDKttFw3KgPCGoCmSNOAJddQpkOjZoCN-m0F_5p-AqxzQRpzWqhfjyDkgy9Ty59pSNcpF4qljrePyYPoZ4Qnd_WcfHn39vPFh-7q4_vLizdXXZBGlC5yzYa99WBZlDAOflBj6-3Qa9BiH42S2sphNEYHaWU_Bhh4a4WONkTr5Tl5ccrdcvpeAYtbJgwwz36FVNEJJnprOFOioc__QW9Sze3hvyizZ4r3qlH8RIWcEDNEt-Vpab_nOHNHOe4kxzU57ijHmbbz7C65DguMfzZ-22iAOAHYRus3yH9P_z_1J6ZbnEw</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Konnerth, Dinah</creator><creator>Schwarz, Florian</creator><creator>Probst, Michael</creator><creator>Seidler, Martin</creator><creator>Wagner, Tanja</creator><creator>Faul, Christian</creator><creator>von Scheidt, Wolfgang</creator><creator>Schwaiblmair, Martin</creator><creator>Berghaus, Thomas M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8551-6190</orcidid></search><sort><creationdate>20180801</creationdate><title>Is acute pulmonary embolism more severe in the presence of obstructive sleep apnea? Results from an observational cohort study</title><author>Konnerth, Dinah ; Schwarz, Florian ; Probst, Michael ; Seidler, Martin ; Wagner, Tanja ; Faul, Christian ; von Scheidt, Wolfgang ; Schwaiblmair, Martin ; Berghaus, Thomas M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-f160b49ae90f3edbab5de909b86e624f753693bd776c3938dceb16c326f9cf9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Apnea</topic><topic>Calcium-binding protein</topic><topic>Cardiology</topic><topic>Cohort analysis</topic><topic>Embolism</topic><topic>Embolisms</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>Hematology</topic><topic>Hypoxemia</topic><topic>Lung diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Observational studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary embolisms</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep disorders</topic><topic>Troponin</topic><topic>Troponin I</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Konnerth, Dinah</creatorcontrib><creatorcontrib>Schwarz, Florian</creatorcontrib><creatorcontrib>Probst, Michael</creatorcontrib><creatorcontrib>Seidler, Martin</creatorcontrib><creatorcontrib>Wagner, Tanja</creatorcontrib><creatorcontrib>Faul, Christian</creatorcontrib><creatorcontrib>von Scheidt, Wolfgang</creatorcontrib><creatorcontrib>Schwaiblmair, Martin</creatorcontrib><creatorcontrib>Berghaus, Thomas M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Konnerth, Dinah</au><au>Schwarz, Florian</au><au>Probst, Michael</au><au>Seidler, Martin</au><au>Wagner, Tanja</au><au>Faul, Christian</au><au>von Scheidt, Wolfgang</au><au>Schwaiblmair, Martin</au><au>Berghaus, Thomas M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is acute pulmonary embolism more severe in the presence of obstructive sleep apnea? Results from an observational cohort study</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>46</volume><issue>2</issue><spage>253</spage><epage>259</epage><pages>253-259</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p < 0.001), had significantly impaired renal (p < 0.001) and left ventricular functions (p = 0.003), showed significantly elevated troponin I (p = 0.005) and D-dimer levels (p = 0.024), were hospitalised significantly longer (p < 0.001), and had significantly elevated PE severity scores (p = 0.015). Moderate or severe OSA was significantly (p = 0.006) more frequent among intermediate- and high-risk PE patients (81.0%) compared to the low-risk PE cohort (16.3%). Multiple logistic regression analysis revealed that PE patients in the AHI ≥ 15/h cohort were at significant risk for myocardial injury (p = 0.015). Based on clinical risk stratification models, patients with no relevant OSA syndrome tended to be at a lower risk for short-term mortality (p = 0.068). Acute PE might present more severely in OSA patients, possibly due to nocturnal hypoxemia or OSA-related hypercoagulability.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29675617</pmid><doi>10.1007/s11239-018-1665-7</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8551-6190</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Apnea Calcium-binding protein Cardiology Cohort analysis Embolism Embolisms Health risk assessment Heart Hematology Hypoxemia Lung diseases Medicine Medicine & Public Health Observational studies Pulmonary arteries Pulmonary embolisms Sleep Sleep apnea Sleep disorders Troponin Troponin I Ventricle |
| title | Is acute pulmonary embolism more severe in the presence of obstructive sleep apnea? Results from an observational cohort study |
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