Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells

[Display omitted] Hypertension is considered as one of the cancer progressive factors, and often found comorbidity in cancer patients. Renin-angiotensin system (RAS) plays an important role in the regulation of blood pressure, and angiotensin II (Ang II) is well known pressor peptide associated with...

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Veröffentlicht in:	Biochemical pharmacology 2018-08, Vol.154, p.136-147
Hauptverfasser:	Ishikane, Shin, Hosoda, Hiroshi, Nojiri, Takashi, Tokudome, Takeshi, Mizutani, Tetsuya, Miura, Koichi, Akitake, Yoshiharu, Kimura, Toru, Imamichi, Yoshitaka, Kawabe, Shinya, Toyohira, Yumiko, Yanagihara, Nobuyuki, Takahashi-Yanaga, Fumi, Miyazato, Mikiya, Miyamoto, Kaoru, Kangawa, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecules Angiotensin II Angiotensin II - toxicity Animals Cell Adhesion Molecules - metabolism Cell Proliferation - drug effects Cell Proliferation - physiology Dose-Response Relationship, Drug E-selectin Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Lung metastasis Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - secondary Male Melanoma, Experimental - chemically induced Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Mice, Knockout Random Allocation Vascular endothelial cells
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