Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates

Multiple System Atrophy (MSA) is a progressive neurodegenerative disease characterized by chronic neuroinflammation and widespread α-synuclein (α-syn) cytoplasmic inclusions. Neuroinflammation associated with microglial cells is typically located in brain regions with α-syn deposits. The potential l...

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Veröffentlicht in:	Molecular and cellular neuroscience 2018-06, Vol.89, p.80-94
Hauptverfasser:	Valdinocci, Dario, Grant, Gary D., Dickson, Tracey C., Pountney, Dean L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alpha-synuclein alpha-Synuclein - metabolism Animals Brain - metabolism Brain - pathology Cell Line Cell Line, Tumor Cell Movement Epothilione D Epothilones - pharmacology Humans Microglia Microglia - drug effects Microglia - metabolism Microglia - physiology Microtubule Multiple System Atrophy Multiple System Atrophy - metabolism Multiple System Atrophy - pathology Rats Tubulin Modulators - pharmacology
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