Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis

Reticulocalbin 3 (Rcn3) is an endoplasmic reticulum (ER) lumen protein localized to the secretory pathway. We have reported that Rcn3 plays a critical role in alveolar epithelial type II cell maturation during perinatal lung development, but its biological role in the adult lung is largely unknown....

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2018-09, Vol.59 (3), p.320-333
Hauptverfasser:	Jin, Jiawei, Shi, Xiaoqian, Li, Yongchao, Zhang, Qianyu, Guo, Yu, Li, Chaokun, Tan, Pingping, Fang, Qiuhong, Ma, Yingmin, Ma, Runlin Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology Alveoli Animals Apoptosis Bleomycin Bleomycin - pharmacology Calcium-Binding Proteins - deficiency Calcium-Binding Proteins - metabolism Clonal deletion Endoplasmic reticulum Epithelial cells Epithelium Fibroblasts Fibrosis Lung - metabolism Lung diseases Mesenchyme Mice, Transgenic Morphogenesis - physiology Pathogenesis Phenotype Phospholipids - metabolism Proteins Pulmonary fibrosis Respiratory Insufficiency - metabolism Thapsigargin Transgenic mice Tunicamycin Wound healing
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