E3 ubiquitin ligase RNF123 targets lamin B1 and lamin‐binding proteins

Lamins are key nuclear proteins which are important for maintaining nuclear structure and function. Mutations in lamins cause a spectrum of genetic diseases termed as laminopathies. RING finger containing E3 ubiquitin ligase, RNF123, is transcriptionally upregulated in cells expressing rod domain la...

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Veröffentlicht in:	The FEBS journal 2018-06, Vol.285 (12), p.2243-2262
Hauptverfasser:	Khanna, Richa, Krishnamoorthy, Vidhya, Parnaik, Veena K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Cancer Cell cycle Cell Nucleus - metabolism Cell Proliferation Cloning, Molecular Degradation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Genes, Reporter Green Fluorescent Proteins HEK293 Cells HeLa Cells Humans Kinetics Lamin Type A - genetics Lamin Type A - metabolism Lamin Type B - genetics Lamin Type B - metabolism laminopathy Lamins Mass Spectrometry Mass spectroscopy Membrane Proteins - genetics Membrane Proteins - metabolism Mutants Mutation nuclear lamina nuclear organization Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear structure Plasmids - chemistry Plasmids - metabolism Proteasome Endopeptidase Complex - metabolism Proteasomes protein degradation Protein Processing, Post-Translational Proteins Proteolysis Recombinant Proteins - genetics Recombinant Proteins - metabolism Retina Retinoblastoma Retinoblastoma protein Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism Structure-function relationships Transcription Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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