A potential strategy for treating atherosclerosis: improving endothelial function via AMP-activated protein kinase

Endothelial dysfunction is caused by many factors, such as dyslipidemia, endoplasmic reticulum (ER) stress, and inflammation. It has been demonstrated that endothelial dysfunction is the initial process of atherosclerosis. AMP-activated protein kinase (AMPK) is an important metabolic switch that pla...

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Veröffentlicht in:	Science China. Life sciences 2018-09, Vol.61 (9), p.1024-1029
Hauptverfasser:	Gao, Feng, Chen, Jiemei, Zhu, Haibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Arteriosclerosis Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - physiopathology Atherosclerosis - therapy Bioavailability Biomedical and Life Sciences Dyslipidemia Endoplasmic reticulum Endoplasmic Reticulum Stress Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Humans Hyperglycemia Inflammation Inflammation - metabolism Inflammation - physiopathology Kinases Life Sciences Lipid metabolism Mitochondria NAD(P)H oxidase Nitric oxide Nitric Oxide - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Review Risk factors Signal Transduction
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