Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats
Epidemiological investigations indicate that chronic arsenic exposure can damage neurobehavioral function in children. The present study was aimed to study the effects of arsenic exposure from drinking water on the spatial memory, and hippocampal ultra-structures and N-methyl- d-aspartate receptor (...
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| Veröffentlicht in: | Toxicology letters 2009-01, Vol.184 (2), p.121-125 |
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| creator | Luo, Jiao-hua Qiu, Zhi-qun Shu, Wei-qun Zhang, Yong-yan Zhang, Liang Chen, Ji-an |
| description | Epidemiological investigations indicate that chronic arsenic exposure can damage neurobehavioral function in children. The present study was aimed to study the effects of arsenic exposure from drinking water on the spatial memory, and hippocampal ultra-structures and N-methyl-
d-aspartate receptor (NMDAR) gene expression in rats. Sprague–Dawley rats were assigned to four groups: rats in control group drank regular water, rats in other groups drank water with final arsenic concentration of 2.72
mg/L (group A), 13.6
mg/L (group B) and 68
mg/L (group C), respectively, for 3 months. The levels of arsenic in blood serum and hippocampus were monitored. Rats were tested in Morris water maze (MWM) for memory status. Samples of hippocampus were collected from two rats in each group for transmission electron microscopic study and the detection of NMDAR expression by RT-PCR. The rats in group C showed a significant delay in hidden platform acquisition. Neurons and endothelial cells presented pathological changes and the expression of NR2A was down-regulated in hippocampus in arsenic exposed rats. Our data indicated that arsenic exposure of 68
mg/L caused spatial memory damage, of which the morphological and biochemical bases could be the ultra-structure changes and reduced NR2A expression in hippocampus. |
| doi_str_mv | 10.1016/j.toxlet.2008.10.029 |
| format | Article |
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d-aspartate receptor (NMDAR) gene expression in rats. Sprague–Dawley rats were assigned to four groups: rats in control group drank regular water, rats in other groups drank water with final arsenic concentration of 2.72
mg/L (group A), 13.6
mg/L (group B) and 68
mg/L (group C), respectively, for 3 months. The levels of arsenic in blood serum and hippocampus were monitored. Rats were tested in Morris water maze (MWM) for memory status. Samples of hippocampus were collected from two rats in each group for transmission electron microscopic study and the detection of NMDAR expression by RT-PCR. The rats in group C showed a significant delay in hidden platform acquisition. Neurons and endothelial cells presented pathological changes and the expression of NR2A was down-regulated in hippocampus in arsenic exposed rats. Our data indicated that arsenic exposure of 68
mg/L caused spatial memory damage, of which the morphological and biochemical bases could be the ultra-structure changes and reduced NR2A expression in hippocampus.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/j.toxlet.2008.10.029</identifier><identifier>PMID: 19041379</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Arsenic ; Arsenites - blood ; Arsenites - toxicity ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dose-Response Relationship, Drug ; Gene Expression - drug effects ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hippocampus - ultrastructure ; Male ; Maze Learning - drug effects ; Medical sciences ; Memory - drug effects ; Metals and various inorganic compounds ; Microscopy, Electron, Transmission ; Morris water maze ; NMDAR ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate - genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Sodium Compounds - blood ; Sodium Compounds - toxicity ; Spatial Behavior - drug effects ; Time Factors ; Toxicology ; Tumors ; Ultra-structure ; Water Pollutants, Chemical - blood ; Water Pollutants, Chemical - toxicity</subject><ispartof>Toxicology letters, 2009-01, Vol.184 (2), p.121-125</ispartof><rights>2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-99ed92f46033a6e5d6270c6064d086cced5ea24972393d6442e1467dff252ad63</citedby><cites>FETCH-LOGICAL-c487t-99ed92f46033a6e5d6270c6064d086cced5ea24972393d6442e1467dff252ad63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxlet.2008.10.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21100374$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19041379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Jiao-hua</creatorcontrib><creatorcontrib>Qiu, Zhi-qun</creatorcontrib><creatorcontrib>Shu, Wei-qun</creatorcontrib><creatorcontrib>Zhang, Yong-yan</creatorcontrib><creatorcontrib>Zhang, Liang</creatorcontrib><creatorcontrib>Chen, Ji-an</creatorcontrib><title>Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>Epidemiological investigations indicate that chronic arsenic exposure can damage neurobehavioral function in children. The present study was aimed to study the effects of arsenic exposure from drinking water on the spatial memory, and hippocampal ultra-structures and N-methyl-
d-aspartate receptor (NMDAR) gene expression in rats. Sprague–Dawley rats were assigned to four groups: rats in control group drank regular water, rats in other groups drank water with final arsenic concentration of 2.72
mg/L (group A), 13.6
mg/L (group B) and 68
mg/L (group C), respectively, for 3 months. The levels of arsenic in blood serum and hippocampus were monitored. Rats were tested in Morris water maze (MWM) for memory status. Samples of hippocampus were collected from two rats in each group for transmission electron microscopic study and the detection of NMDAR expression by RT-PCR. The rats in group C showed a significant delay in hidden platform acquisition. Neurons and endothelial cells presented pathological changes and the expression of NR2A was down-regulated in hippocampus in arsenic exposed rats. Our data indicated that arsenic exposure of 68
mg/L caused spatial memory damage, of which the morphological and biochemical bases could be the ultra-structure changes and reduced NR2A expression in hippocampus.</description><subject>Animals</subject><subject>Arsenic</subject><subject>Arsenites - blood</subject><subject>Arsenites - toxicity</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gene Expression - drug effects</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - ultrastructure</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Metals and various inorganic compounds</subject><subject>Microscopy, Electron, Transmission</subject><subject>Morris water maze</subject><subject>NMDAR</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, N-Methyl-D-Aspartate - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sodium Compounds - blood</subject><subject>Sodium Compounds - toxicity</subject><subject>Spatial Behavior - drug effects</subject><subject>Time Factors</subject><subject>Toxicology</subject><subject>Tumors</subject><subject>Ultra-structure</subject><subject>Water Pollutants, Chemical - blood</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-PFCEQxYnRuOvqNzCGi57sEWiGbi4mm3X9k6yaGD0ThGJl7IaWonX37geXyUz05onk5fdeUa8IeczZhjOuXuw2Nd9MUDeCsbFJGyb0HXLKx0F3PVf6Ljll_TB2UgzyhDxA3DHGlFTb--SEayZ5P-hT8vsyBHAVaQ7UFoQUHYWbJeNagIaSZ-pLTN9juqa_bIVCc6K42BrtRGeYc7l9TtepFtthLaurzYbUJk8_vH91_oleQ4J9XlMxNmub8i0uS3Z2XlakMdFiKz4k94KdEB4d3zPy5fXl54u33dXHN-8uzq86J8ehdlqD1yJIxfreKth6JQbmVFvKs1E5B34LVkg9iF73XkkpgEs1-BDEVliv-jPy7JC7lPxjBaxmjuhgmmyCvKIRTIxMDryB8gC6khELBLOUONtyazgz-_bNzhzaN_v292prv9meHPPXrzP4f6Zj3Q14egQsOjuFYpOL-JcTnLN2M9m4lwcOWhs_IxSDLkJqG8bSrmV8jv__yR9md6by</recordid><startdate>20090130</startdate><enddate>20090130</enddate><creator>Luo, Jiao-hua</creator><creator>Qiu, Zhi-qun</creator><creator>Shu, Wei-qun</creator><creator>Zhang, Yong-yan</creator><creator>Zhang, Liang</creator><creator>Chen, Ji-an</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20090130</creationdate><title>Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats</title><author>Luo, Jiao-hua ; Qiu, Zhi-qun ; Shu, Wei-qun ; Zhang, Yong-yan ; Zhang, Liang ; Chen, Ji-an</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-99ed92f46033a6e5d6270c6064d086cced5ea24972393d6442e1467dff252ad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Arsenic</topic><topic>Arsenites - blood</topic><topic>Arsenites - toxicity</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gene Expression - drug effects</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - ultrastructure</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Metals and various inorganic compounds</topic><topic>Microscopy, Electron, Transmission</topic><topic>Morris water maze</topic><topic>NMDAR</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, N-Methyl-D-Aspartate - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sodium Compounds - blood</topic><topic>Sodium Compounds - toxicity</topic><topic>Spatial Behavior - drug effects</topic><topic>Time Factors</topic><topic>Toxicology</topic><topic>Tumors</topic><topic>Ultra-structure</topic><topic>Water Pollutants, Chemical - blood</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Jiao-hua</creatorcontrib><creatorcontrib>Qiu, Zhi-qun</creatorcontrib><creatorcontrib>Shu, Wei-qun</creatorcontrib><creatorcontrib>Zhang, Yong-yan</creatorcontrib><creatorcontrib>Zhang, Liang</creatorcontrib><creatorcontrib>Chen, Ji-an</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Jiao-hua</au><au>Qiu, Zhi-qun</au><au>Shu, Wei-qun</au><au>Zhang, Yong-yan</au><au>Zhang, Liang</au><au>Chen, Ji-an</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2009-01-30</date><risdate>2009</risdate><volume>184</volume><issue>2</issue><spage>121</spage><epage>125</epage><pages>121-125</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Epidemiological investigations indicate that chronic arsenic exposure can damage neurobehavioral function in children. The present study was aimed to study the effects of arsenic exposure from drinking water on the spatial memory, and hippocampal ultra-structures and N-methyl-
d-aspartate receptor (NMDAR) gene expression in rats. Sprague–Dawley rats were assigned to four groups: rats in control group drank regular water, rats in other groups drank water with final arsenic concentration of 2.72
mg/L (group A), 13.6
mg/L (group B) and 68
mg/L (group C), respectively, for 3 months. The levels of arsenic in blood serum and hippocampus were monitored. Rats were tested in Morris water maze (MWM) for memory status. Samples of hippocampus were collected from two rats in each group for transmission electron microscopic study and the detection of NMDAR expression by RT-PCR. The rats in group C showed a significant delay in hidden platform acquisition. Neurons and endothelial cells presented pathological changes and the expression of NR2A was down-regulated in hippocampus in arsenic exposed rats. Our data indicated that arsenic exposure of 68
mg/L caused spatial memory damage, of which the morphological and biochemical bases could be the ultra-structure changes and reduced NR2A expression in hippocampus.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19041379</pmid><doi>10.1016/j.toxlet.2008.10.029</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Arsenic Arsenites - blood Arsenites - toxicity Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Gene Expression - drug effects Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - ultrastructure Male Maze Learning - drug effects Medical sciences Memory - drug effects Metals and various inorganic compounds Microscopy, Electron, Transmission Morris water maze NMDAR Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - genetics Reverse Transcriptase Polymerase Chain Reaction Sodium Compounds - blood Sodium Compounds - toxicity Spatial Behavior - drug effects Time Factors Toxicology Tumors Ultra-structure Water Pollutants, Chemical - blood Water Pollutants, Chemical - toxicity |
| title | Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats |
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