In vivo behaviour of antibody-drug conjugates for the targeted treatment of cancer

It is a commonly held belief that most treatments for disseminated cancers are only moderately effective because the agents lack cell-killing mechanisms that act specifically on cancer cells. In antibody-drug conjugates, such nonspecific cytotoxic agents are combined with exquisitely specific monocl...

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Veröffentlicht in:	Expert opinion on biological therapy 2006-03, Vol.6 (3), p.281-291
Hauptverfasser:	Xie, Hongsheng, Blättler, Walter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neoplasm - administration & dosage Antibodies, Neoplasm - metabolism antibody-drug conjugates anticancer agents Antineoplastic Agents - administration & dosage Drug Delivery Systems - methods Humans Immunoconjugates - administration & dosage in vivo evaluation Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism pharmacokinetics pharmacology
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