High-Affinity Binding of Southern African HIV Type 1 Subtype C Envelope Protein, gp120, to the CCR5 Coreceptor

HIV-1 subtype C is the fastest spreading subtype worldwide and predominantly uses the CCR5 coreceptor, showing minimal transition to the X4 phenotype. This raises the possibility that envelope proteins of HIV-1 subtype C have structural features that favor interaction with CCR5. Preference for CCR5...

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Veröffentlicht in:	AIDS research and human retroviruses 2008-12, Vol.24 (12), p.1527-1536
Hauptverfasser:	FROMME, Bernhard J, COETSEE, Maria, VAN DER WATT, Pauline, CHAN, Mei-Chi, SPERLING, Karin M, KATZ, Arieh A, FLANAGAN, Colleen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - virology Africa, Southern Amino Acid Substitution - genetics Biological and medical sciences CD4 Antigens - metabolism Chemokine receptors Distribution Fundamental and applied biological sciences. Psychology Genetic aspects Glycoproteins Health aspects HIV (Viruses) HIV Envelope Protein gp120 - metabolism HIV-1 - isolation & purification HIV-1 - physiology Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Medical sciences Microbiology Miscellaneous Mutagenesis, Site-Directed Mutation, Missense Protein Binding Receptors, CCR5 - metabolism Retrovirus Viral diseases Virology
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