3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system

[Display omitted] Here in, we report the preparation and evaluation of four 3-hydroxy-piperidine-N-benzyl-aryl-acylhydrazone derivatives (6a–d) for their potential antinociceptive activity. In the tail flick test, compounds 6a and 6d exhibited a significant increase in the latency time of the animal...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2018-03, Vol.99, p.492-498
Hauptverfasser:	dos Santos, Nathália M., Pereira, Nayara C., de Albuquerque, Angélica P.S., Dias Viegas, Flávia P., Veloso, Clarice, Vilela, Fabiana C., Giusti-Paiva, Alexandre, da Silva, Marcelo L., da Silva, Josie R.T., Viegas Jr, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antinociceptive activity N-acylhydrazones Neuropathic pain Opioid Pain
Online-Zugang:	Volltext
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