3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system
[Display omitted] Here in, we report the preparation and evaluation of four 3-hydroxy-piperidine-N-benzyl-aryl-acylhydrazone derivatives (6a–d) for their potential antinociceptive activity. In the tail flick test, compounds 6a and 6d exhibited a significant increase in the latency time of the animal...
Gespeichert in:
| Veröffentlicht in: | Biomedicine & pharmacotherapy 2018-03, Vol.99, p.492-498 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 498 |
|---|---|
| container_issue | |
| container_start_page | 492 |
| container_title | Biomedicine & pharmacotherapy |
| container_volume | 99 |
| creator | dos Santos, Nathália M. Pereira, Nayara C. de Albuquerque, Angélica P.S. Dias Viegas, Flávia P. Veloso, Clarice Vilela, Fabiana C. Giusti-Paiva, Alexandre da Silva, Marcelo L. da Silva, Josie R.T. Viegas Jr, Claudio |
| description | [Display omitted]
Here in, we report the preparation and evaluation of four 3-hydroxy-piperidine-N-benzyl-aryl-acylhydrazone derivatives (6a–d) for their potential antinociceptive activity. In the tail flick test, compounds 6a and 6d exhibited a significant increase in the latency time of the animals, in comparison to the control group. These two compounds also showed a significant increase in the nociceptive threshold from 1 to 6 h after treatment in the CCI neuropathic pain model. In both cases, the antinociceptive activity was blocked by naloxone, suggesting an opioid mechanism of action, but without sedative or motor coordination effects. |
| doi_str_mv | 10.1016/j.biopha.2018.01.077 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2027070161</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S075333221736256X</els_id><sourcerecordid>2027070161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-35471a3ea36717fb28e1996ca57a978b7b2113ffed68318b45fc10ec996d3c343</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxi1ERbeFN0DIRy5O_WdjJxckVAGtVMEFzpZjTxSvEjvYyYr0IfrMeLWFYy8zc_jNjL7vQ-g9oxWjTN4cqs7HeTAVp6ypKKuoUq_QjrU1JZJS9RrtqKoFEYLzS3SV84FSWkvRvEGXvJWyljXboSdB7jaX4p-NzH6G5J0P20i-kw7CYxmMPZW0jUOhzGMMgF2hjmbxR8g4gVst4ABrirNZBm_xbHzAJjjsg01gMuBlgDSZsfQEeYijwxM4bxZwuNtwnH30DuctLzC9RRe9GTO8e-7X6NfXLz9v78jDj2_3t58fiBWSL0TUe8WMACOkYqrveAOsbaU1tTKtajrVccZE34OTjWBNt697yyjYwjhhxV5co4_nu3OKv1fIi558tjCOJkBcs-aUK6qKzayg-zNqU8w5Qa_n5KdiiWZUn5LQB31OQp-S0JTpkkRZ-_D8Ye2K3P9L_6wvwKczAEXn0UPS2XoItliTwC7aRf_yh7_92Z9j</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2027070161</pqid></control><display><type>article</type><title>3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system</title><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>dos Santos, Nathália M. ; Pereira, Nayara C. ; de Albuquerque, Angélica P.S. ; Dias Viegas, Flávia P. ; Veloso, Clarice ; Vilela, Fabiana C. ; Giusti-Paiva, Alexandre ; da Silva, Marcelo L. ; da Silva, Josie R.T. ; Viegas Jr, Claudio</creator><creatorcontrib>dos Santos, Nathália M. ; Pereira, Nayara C. ; de Albuquerque, Angélica P.S. ; Dias Viegas, Flávia P. ; Veloso, Clarice ; Vilela, Fabiana C. ; Giusti-Paiva, Alexandre ; da Silva, Marcelo L. ; da Silva, Josie R.T. ; Viegas Jr, Claudio</creatorcontrib><description>[Display omitted]
Here in, we report the preparation and evaluation of four 3-hydroxy-piperidine-N-benzyl-aryl-acylhydrazone derivatives (6a–d) for their potential antinociceptive activity. In the tail flick test, compounds 6a and 6d exhibited a significant increase in the latency time of the animals, in comparison to the control group. These two compounds also showed a significant increase in the nociceptive threshold from 1 to 6 h after treatment in the CCI neuropathic pain model. In both cases, the antinociceptive activity was blocked by naloxone, suggesting an opioid mechanism of action, but without sedative or motor coordination effects.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2018.01.077</identifier><identifier>PMID: 29665651</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Antinociceptive activity ; N-acylhydrazones ; Neuropathic pain ; Opioid ; Pain</subject><ispartof>Biomedicine & pharmacotherapy, 2018-03, Vol.99, p.492-498</ispartof><rights>2018 Elsevier Masson SAS</rights><rights>Copyright © 2018 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-35471a3ea36717fb28e1996ca57a978b7b2113ffed68318b45fc10ec996d3c343</citedby><cites>FETCH-LOGICAL-c362t-35471a3ea36717fb28e1996ca57a978b7b2113ffed68318b45fc10ec996d3c343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S075333221736256X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29665651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>dos Santos, Nathália M.</creatorcontrib><creatorcontrib>Pereira, Nayara C.</creatorcontrib><creatorcontrib>de Albuquerque, Angélica P.S.</creatorcontrib><creatorcontrib>Dias Viegas, Flávia P.</creatorcontrib><creatorcontrib>Veloso, Clarice</creatorcontrib><creatorcontrib>Vilela, Fabiana C.</creatorcontrib><creatorcontrib>Giusti-Paiva, Alexandre</creatorcontrib><creatorcontrib>da Silva, Marcelo L.</creatorcontrib><creatorcontrib>da Silva, Josie R.T.</creatorcontrib><creatorcontrib>Viegas Jr, Claudio</creatorcontrib><title>3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>[Display omitted]
Here in, we report the preparation and evaluation of four 3-hydroxy-piperidine-N-benzyl-aryl-acylhydrazone derivatives (6a–d) for their potential antinociceptive activity. In the tail flick test, compounds 6a and 6d exhibited a significant increase in the latency time of the animals, in comparison to the control group. These two compounds also showed a significant increase in the nociceptive threshold from 1 to 6 h after treatment in the CCI neuropathic pain model. In both cases, the antinociceptive activity was blocked by naloxone, suggesting an opioid mechanism of action, but without sedative or motor coordination effects.</description><subject>Antinociceptive activity</subject><subject>N-acylhydrazones</subject><subject>Neuropathic pain</subject><subject>Opioid</subject><subject>Pain</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQxi1ERbeFN0DIRy5O_WdjJxckVAGtVMEFzpZjTxSvEjvYyYr0IfrMeLWFYy8zc_jNjL7vQ-g9oxWjTN4cqs7HeTAVp6ypKKuoUq_QjrU1JZJS9RrtqKoFEYLzS3SV84FSWkvRvEGXvJWyljXboSdB7jaX4p-NzH6G5J0P20i-kw7CYxmMPZW0jUOhzGMMgF2hjmbxR8g4gVst4ABrirNZBm_xbHzAJjjsg01gMuBlgDSZsfQEeYijwxM4bxZwuNtwnH30DuctLzC9RRe9GTO8e-7X6NfXLz9v78jDj2_3t58fiBWSL0TUe8WMACOkYqrveAOsbaU1tTKtajrVccZE34OTjWBNt697yyjYwjhhxV5co4_nu3OKv1fIi558tjCOJkBcs-aUK6qKzayg-zNqU8w5Qa_n5KdiiWZUn5LQB31OQp-S0JTpkkRZ-_D8Ye2K3P9L_6wvwKczAEXn0UPS2XoItliTwC7aRf_yh7_92Z9j</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>dos Santos, Nathália M.</creator><creator>Pereira, Nayara C.</creator><creator>de Albuquerque, Angélica P.S.</creator><creator>Dias Viegas, Flávia P.</creator><creator>Veloso, Clarice</creator><creator>Vilela, Fabiana C.</creator><creator>Giusti-Paiva, Alexandre</creator><creator>da Silva, Marcelo L.</creator><creator>da Silva, Josie R.T.</creator><creator>Viegas Jr, Claudio</creator><general>Elsevier Masson SAS</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201803</creationdate><title>3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system</title><author>dos Santos, Nathália M. ; Pereira, Nayara C. ; de Albuquerque, Angélica P.S. ; Dias Viegas, Flávia P. ; Veloso, Clarice ; Vilela, Fabiana C. ; Giusti-Paiva, Alexandre ; da Silva, Marcelo L. ; da Silva, Josie R.T. ; Viegas Jr, Claudio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-35471a3ea36717fb28e1996ca57a978b7b2113ffed68318b45fc10ec996d3c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antinociceptive activity</topic><topic>N-acylhydrazones</topic><topic>Neuropathic pain</topic><topic>Opioid</topic><topic>Pain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>dos Santos, Nathália M.</creatorcontrib><creatorcontrib>Pereira, Nayara C.</creatorcontrib><creatorcontrib>de Albuquerque, Angélica P.S.</creatorcontrib><creatorcontrib>Dias Viegas, Flávia P.</creatorcontrib><creatorcontrib>Veloso, Clarice</creatorcontrib><creatorcontrib>Vilela, Fabiana C.</creatorcontrib><creatorcontrib>Giusti-Paiva, Alexandre</creatorcontrib><creatorcontrib>da Silva, Marcelo L.</creatorcontrib><creatorcontrib>da Silva, Josie R.T.</creatorcontrib><creatorcontrib>Viegas Jr, Claudio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>dos Santos, Nathália M.</au><au>Pereira, Nayara C.</au><au>de Albuquerque, Angélica P.S.</au><au>Dias Viegas, Flávia P.</au><au>Veloso, Clarice</au><au>Vilela, Fabiana C.</au><au>Giusti-Paiva, Alexandre</au><au>da Silva, Marcelo L.</au><au>da Silva, Josie R.T.</au><au>Viegas Jr, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2018-03</date><risdate>2018</risdate><volume>99</volume><spage>492</spage><epage>498</epage><pages>492-498</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>[Display omitted]
Here in, we report the preparation and evaluation of four 3-hydroxy-piperidine-N-benzyl-aryl-acylhydrazone derivatives (6a–d) for their potential antinociceptive activity. In the tail flick test, compounds 6a and 6d exhibited a significant increase in the latency time of the animals, in comparison to the control group. These two compounds also showed a significant increase in the nociceptive threshold from 1 to 6 h after treatment in the CCI neuropathic pain model. In both cases, the antinociceptive activity was blocked by naloxone, suggesting an opioid mechanism of action, but without sedative or motor coordination effects.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>29665651</pmid><doi>10.1016/j.biopha.2018.01.077</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0753-3322 |
| ispartof | Biomedicine & pharmacotherapy, 2018-03, Vol.99, p.492-498 |
| issn | 0753-3322 1950-6007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2027070161 |
| source | Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antinociceptive activity N-acylhydrazones Neuropathic pain Opioid Pain |
| title | 3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T08%3A27%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone%20derivatives%20reduce%20neuropathic%20pain%20and%20increase%20thermal%20threshold%20mediated%20by%20opioid%20system&rft.jtitle=Biomedicine%20&%20pharmacotherapy&rft.au=dos%20Santos,%20Nath%C3%A1lia%20M.&rft.date=2018-03&rft.volume=99&rft.spage=492&rft.epage=498&rft.pages=492-498&rft.issn=0753-3322&rft.eissn=1950-6007&rft_id=info:doi/10.1016/j.biopha.2018.01.077&rft_dat=%3Cproquest_cross%3E2027070161%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2027070161&rft_id=info:pmid/29665651&rft_els_id=S075333221736256X&rfr_iscdi=true |