Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary α-klotho deficiency and perturbed phosphate homeostasis

Loss of ubiquitin COOH-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme required for neuronal function, led to hyperphosphatemia accompanied by phosphaturia in mice, while calcium homeostasis remained intact. We therefore investigated the mechanisms underlying the phosphate imbalance in Uchl...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2018-08, Vol.315 (2), p.F353-F363
Hauptverfasser:	Boisvert, Naomi C, Holterman, Chet E, Gutsol, Alexey, Coulombe, Josée, Pan, Wanling, Alexander, R Todd, Gray, Douglas A, Kennedy, Chris R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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