The rs1256031 of estrogen receptor β gene is associated with type 2 diabetes
To determine the association between the rs1256031 polymorphism and risk of developing type 2 diabetes. Cases and controls study. 597 individuals with type 2 diabetes and 605 without it participated. Genotyping of the rs1256031 polymorphism of the ERβ gene was performed by real-time PCR using TaqMan...
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| Veröffentlicht in: | Diabetes & metabolic syndrome clinical research & reviews 2018-09, Vol.12 (5), p.631-633 |
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| creator | Herrera-Lopez, Ema E. Castelan-Martinez, Osvaldo D. Suarez-Sanchez, Fernando Gomez-Zamudio, Jaime H. Peralta-Romero, Jose J. Cruz, Miguel Valladares-Salgado, Adan |
| description | To determine the association between the rs1256031 polymorphism and risk of developing type 2 diabetes.
Cases and controls study. 597 individuals with type 2 diabetes and 605 without it participated. Genotyping of the rs1256031 polymorphism of the ERβ gene was performed by real-time PCR using TaqMan assay. For the multivariate analysis, a multiple logistic regression was performed that included the main confounding variables.
A multiple logistic regression analysis was performed, adjusting for age, WHR, BMI and gender. The dominant model showed a protective effect compared to the TT genotype (OR = 0.596, IC95% [0.458–0.776]). Discussion. The proportions of native American, European and African ancestry were characterized and no difference was found in the study groups. The protective effect obtained in the dominant model could to be due a regulatory function in the transcription or the processing of the primary transcript. Our result are the first to report an association between the polymorphism rs1256031 and the reduction of the risk of T2D in the Mexican population. The rs1256031 polymorphism show reduced risk of developing T2D and is potential markers for predicting T2D. |
| doi_str_mv | 10.1016/j.dsx.2018.04.018 |
| format | Article |
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Cases and controls study. 597 individuals with type 2 diabetes and 605 without it participated. Genotyping of the rs1256031 polymorphism of the ERβ gene was performed by real-time PCR using TaqMan assay. For the multivariate analysis, a multiple logistic regression was performed that included the main confounding variables.
A multiple logistic regression analysis was performed, adjusting for age, WHR, BMI and gender. The dominant model showed a protective effect compared to the TT genotype (OR = 0.596, IC95% [0.458–0.776]). Discussion. The proportions of native American, European and African ancestry were characterized and no difference was found in the study groups. The protective effect obtained in the dominant model could to be due a regulatory function in the transcription or the processing of the primary transcript. Our result are the first to report an association between the polymorphism rs1256031 and the reduction of the risk of T2D in the Mexican population. The rs1256031 polymorphism show reduced risk of developing T2D and is potential markers for predicting T2D.</description><identifier>ISSN: 1871-4021</identifier><identifier>EISSN: 1878-0334</identifier><identifier>DOI: 10.1016/j.dsx.2018.04.018</identifier><identifier>PMID: 29666032</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Case-Control Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; Estrogen Receptor beta - blood ; Estrogen Receptor beta - genetics ; Estrogen receptor β ; Female ; Genotype ; Humans ; Male ; Mexico - epidemiology ; Middle Aged ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; rs1256031 ; Type 2 diabetes</subject><ispartof>Diabetes & metabolic syndrome clinical research & reviews, 2018-09, Vol.12 (5), p.631-633</ispartof><rights>2018 Diabetes India</rights><rights>Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-b3ce8470c0afe2c63d682c657a22ccc1703b9147c0aface02217a829fb5eebf43</citedby><cites>FETCH-LOGICAL-c353t-b3ce8470c0afe2c63d682c657a22ccc1703b9147c0aface02217a829fb5eebf43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dsx.2018.04.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29666032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herrera-Lopez, Ema E.</creatorcontrib><creatorcontrib>Castelan-Martinez, Osvaldo D.</creatorcontrib><creatorcontrib>Suarez-Sanchez, Fernando</creatorcontrib><creatorcontrib>Gomez-Zamudio, Jaime H.</creatorcontrib><creatorcontrib>Peralta-Romero, Jose J.</creatorcontrib><creatorcontrib>Cruz, Miguel</creatorcontrib><creatorcontrib>Valladares-Salgado, Adan</creatorcontrib><title>The rs1256031 of estrogen receptor β gene is associated with type 2 diabetes</title><title>Diabetes & metabolic syndrome clinical research & reviews</title><addtitle>Diabetes Metab Syndr</addtitle><description>To determine the association between the rs1256031 polymorphism and risk of developing type 2 diabetes.
Cases and controls study. 597 individuals with type 2 diabetes and 605 without it participated. Genotyping of the rs1256031 polymorphism of the ERβ gene was performed by real-time PCR using TaqMan assay. For the multivariate analysis, a multiple logistic regression was performed that included the main confounding variables.
A multiple logistic regression analysis was performed, adjusting for age, WHR, BMI and gender. The dominant model showed a protective effect compared to the TT genotype (OR = 0.596, IC95% [0.458–0.776]). Discussion. The proportions of native American, European and African ancestry were characterized and no difference was found in the study groups. The protective effect obtained in the dominant model could to be due a regulatory function in the transcription or the processing of the primary transcript. Our result are the first to report an association between the polymorphism rs1256031 and the reduction of the risk of T2D in the Mexican population. The rs1256031 polymorphism show reduced risk of developing T2D and is potential markers for predicting T2D.</description><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Estrogen Receptor beta - blood</subject><subject>Estrogen Receptor beta - genetics</subject><subject>Estrogen receptor β</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>rs1256031</subject><subject>Type 2 diabetes</subject><issn>1871-4021</issn><issn>1878-0334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOAzEMRSMEoqXwAWxQlmxmcB7zEitU8ZJAbMo6ymQ8NFXbDMkU6G_xIXwTKS0sWV1bvr6yDyGnDFIGLL-YpU34SDmwMgWZRtkjQ1YWZQJCyP2fmiUSOBuQoxBmAFlW8eqQDHiV5zkIPiSPkylSHxjPYs-oaymG3rsXXFKPBrveefr1SWOP1AaqQ3DG6h4b-m77Ke3XHVJOG6tr7DEck4NWzwOe7HREnm-uJ-O75OHp9n589ZAYkYk-qYXBUhZgQLfITS6avIySFZpzYwwrQNQVk8Vmrg0C56zQJa_aOkOsWylG5Hyb23n3uooXq4UNBudzvUS3CooDLyDPZMmjlW2txrsQPLaq83ah_VoxUBuKaqYiRbWhqECqKHHnbBe_qhfY_G38YouGy60B45NvFr0KxuLSYGMjtV41zv4T_w3Sa4Hk</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Herrera-Lopez, Ema E.</creator><creator>Castelan-Martinez, Osvaldo D.</creator><creator>Suarez-Sanchez, Fernando</creator><creator>Gomez-Zamudio, Jaime H.</creator><creator>Peralta-Romero, Jose J.</creator><creator>Cruz, Miguel</creator><creator>Valladares-Salgado, Adan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201809</creationdate><title>The rs1256031 of estrogen receptor β gene is associated with type 2 diabetes</title><author>Herrera-Lopez, Ema E. ; Castelan-Martinez, Osvaldo D. ; Suarez-Sanchez, Fernando ; Gomez-Zamudio, Jaime H. ; Peralta-Romero, Jose J. ; Cruz, Miguel ; Valladares-Salgado, Adan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-b3ce8470c0afe2c63d682c657a22ccc1703b9147c0aface02217a829fb5eebf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Estrogen Receptor beta - blood</topic><topic>Estrogen Receptor beta - genetics</topic><topic>Estrogen receptor β</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Mexico - epidemiology</topic><topic>Middle Aged</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>rs1256031</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herrera-Lopez, Ema E.</creatorcontrib><creatorcontrib>Castelan-Martinez, Osvaldo D.</creatorcontrib><creatorcontrib>Suarez-Sanchez, Fernando</creatorcontrib><creatorcontrib>Gomez-Zamudio, Jaime H.</creatorcontrib><creatorcontrib>Peralta-Romero, Jose J.</creatorcontrib><creatorcontrib>Cruz, Miguel</creatorcontrib><creatorcontrib>Valladares-Salgado, Adan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes & metabolic syndrome clinical research & reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herrera-Lopez, Ema E.</au><au>Castelan-Martinez, Osvaldo D.</au><au>Suarez-Sanchez, Fernando</au><au>Gomez-Zamudio, Jaime H.</au><au>Peralta-Romero, Jose J.</au><au>Cruz, Miguel</au><au>Valladares-Salgado, Adan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rs1256031 of estrogen receptor β gene is associated with type 2 diabetes</atitle><jtitle>Diabetes & metabolic syndrome clinical research & reviews</jtitle><addtitle>Diabetes Metab Syndr</addtitle><date>2018-09</date><risdate>2018</risdate><volume>12</volume><issue>5</issue><spage>631</spage><epage>633</epage><pages>631-633</pages><issn>1871-4021</issn><eissn>1878-0334</eissn><abstract>To determine the association between the rs1256031 polymorphism and risk of developing type 2 diabetes.
Cases and controls study. 597 individuals with type 2 diabetes and 605 without it participated. Genotyping of the rs1256031 polymorphism of the ERβ gene was performed by real-time PCR using TaqMan assay. For the multivariate analysis, a multiple logistic regression was performed that included the main confounding variables.
A multiple logistic regression analysis was performed, adjusting for age, WHR, BMI and gender. The dominant model showed a protective effect compared to the TT genotype (OR = 0.596, IC95% [0.458–0.776]). Discussion. The proportions of native American, European and African ancestry were characterized and no difference was found in the study groups. The protective effect obtained in the dominant model could to be due a regulatory function in the transcription or the processing of the primary transcript. Our result are the first to report an association between the polymorphism rs1256031 and the reduction of the risk of T2D in the Mexican population. The rs1256031 polymorphism show reduced risk of developing T2D and is potential markers for predicting T2D.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>29666032</pmid><doi>10.1016/j.dsx.2018.04.018</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Aged Case-Control Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Estrogen Receptor beta - blood Estrogen Receptor beta - genetics Estrogen receptor β Female Genotype Humans Male Mexico - epidemiology Middle Aged Polymorphism Polymorphism, Single Nucleotide - genetics rs1256031 Type 2 diabetes |
| title | The rs1256031 of estrogen receptor β gene is associated with type 2 diabetes |
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