Cytotoxicity and immunostimulation: double attack on cancer cells with polymeric therapeutics
The successful treatment of cancer with conventional drugs is frequently complicated by the resistance of tumor cells to such a non-specific therapy. Over the last few years, immunotherapy has gained attention as a tumor-specific approach. Recent findings demonstrated that some conventional cytostat...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2009-01, Vol.27 (1), p.11-17 |
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| creator | Říhová, Blanka Kovář, Lubomír Kovář, Marek Hovorka, Ondřej |
| description | The successful treatment of cancer with conventional drugs is frequently complicated by the resistance of tumor cells to such a non-specific therapy. Over the last few years, immunotherapy has gained attention as a tumor-specific approach. Recent findings demonstrated that some conventional cytostatics stimulate local anticancer responses. New anticancer drugs, including their polymeric derivatives, are currently being developed with the aim of destroying tumors more effectively and more specifically. Among these, the water-soluble conjugates of doxorubicin with N- (2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier have emerged as efficient therapeutics because they are able to not only directly destroy cancer cells but also elicit systemic tumor-specific anticancer responses. Here, we discuss new insights into their mechanisms of immune surveillance, which could suggest novel approaches to cancer therapy. |
| doi_str_mv | 10.1016/j.tibtech.2008.10.006 |
| format | Article |
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Over the last few years, immunotherapy has gained attention as a tumor-specific approach. Recent findings demonstrated that some conventional cytostatics stimulate local anticancer responses. New anticancer drugs, including their polymeric derivatives, are currently being developed with the aim of destroying tumors more effectively and more specifically. Among these, the water-soluble conjugates of doxorubicin with N- (2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier have emerged as efficient therapeutics because they are able to not only directly destroy cancer cells but also elicit systemic tumor-specific anticancer responses. 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Pharmaceutical industry ; Humans ; Immune system ; Immunologic Factors - administration & dosage ; Immunotherapy ; Industrial applications and implications. Economical aspects ; Internal Medicine ; Medical research ; Medical sciences ; Miscellaneous ; Models, Biological ; Neoplasms - drug therapy ; Neoplasms - immunology ; Pharmacology. 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Over the last few years, immunotherapy has gained attention as a tumor-specific approach. Recent findings demonstrated that some conventional cytostatics stimulate local anticancer responses. New anticancer drugs, including their polymeric derivatives, are currently being developed with the aim of destroying tumors more effectively and more specifically. Among these, the water-soluble conjugates of doxorubicin with N- (2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier have emerged as efficient therapeutics because they are able to not only directly destroy cancer cells but also elicit systemic tumor-specific anticancer responses. 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| subjects | Adjuvants, Immunologic - administration & dosage Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Apoptosis Biological and medical sciences Biotechnology Cancer Chemotherapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cytotoxicity Cytotoxins - administration & dosage Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Humans Immune system Immunologic Factors - administration & dosage Immunotherapy Industrial applications and implications. Economical aspects Internal Medicine Medical research Medical sciences Miscellaneous Models, Biological Neoplasms - drug therapy Neoplasms - immunology Pharmacology. Drug treatments Polymers - administration & dosage Tumors |
| title | Cytotoxicity and immunostimulation: double attack on cancer cells with polymeric therapeutics |
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